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MedKoo Cat#: 592542 | Name: Diethylstilbestrol dipropionate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylstilbestrol dipropionate is used in estrogen therapy of relapsed prostate cancer.

Chemical Structure

Diethylstilbestrol dipropionate
CAS#130-80-3

Theoretical Analysis

MedKoo Cat#: 592542

Name: Diethylstilbestrol dipropionate

CAS#: 130-80-3

Chemical Formula: C24H28O4

Exact Mass: 380.1988

Molecular Weight: 380.48

Elemental Analysis: C, 75.76; H, 7.42; O, 16.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Diethylstilbestrol dipropionate
IUPAC/Chemical Name
4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipropionate, (E)-
InChi Key
VZMLEMYJUIIHNF-QURGRASLSA-N
InChi Code
InChI=1S/C24H28O4/c1-5-21(17-9-13-19(14-10-17)27-23(25)7-3)22(6-2)18-11-15-20(16-12-18)28-24(26)8-4/h9-16H,5-8H2,1-4H3/b22-21+
SMILES Code
CC/C(C1=CC=C(OC(CC)=O)C=C1)=C(CC)\C2=CC=C(OC(CC)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 380.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hsieh TF, Tseng CJ, Tang JB, Chen YH. A proline rich acidic protein PRAP identified from uterine luminal fluid of estrous mice is able to enhance the estrogen responsiveness of Ishikawa cells. J Cell Biochem. 2011 Nov;112(11):3122-8. doi: 10.1002/jcb.23238. PubMed PMID: 21695714. 2: Nakata S, Miyazawa Y, Sasaki Y, Nakano K, Takahashi H. [Prognostic factors for estrogen therapy of relapsed prostate cancer after maximal androgen blockade (MAB)]. Nihon Hinyokika Gakkai Zasshi. 2010 May;101(4):597-602. Japanese. PubMed PMID: 20535987. 3: Fujinami K, Miura T, Takizawa A, Osada Y. [Combination chemotherapy with docetaxel and cisplatin in patients with hormone-refractory prostate cancer]. Hinyokika Kiyo. 2005 Jan;51(1):5-8. Japanese. PubMed PMID: 15732332. 4: Leaf AN, Propert K, Corcoran C, Catalano PJ, Trump DL, Harris JE, Davis TE. Phase III study of combined chemohormonal therapy in metastatic prostate cancer (ECOG 3882): an Eastern Cooperative Oncology Group study. Med Oncol. 2003;20(2):137-46. PubMed PMID: 12835516. 5: McKim JM Jr, Wilga PC, Breslin WJ, Plotzke KP, Gallavan RH, Meeks RG. Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay. Toxicol Sci. 2001 Sep;63(1):37-46. PubMed PMID: 11509742. 6: Jan CR, Cheng JS, Roan CJ, Lee KC, Chen WC, Chou KJ, Tang KY, Wang JL. Effect of diethylstilbestrol (DES) on intracellular Ca(2+) levels in renal tubular cells. Steroids. 2001 Jun;66(6):505-10. PubMed PMID: 11182139. 7: Limanowski A, Miśkowiak B, Otulakowski B, Partyka M. Morphometric studies on the testes of rats treated neonatally with oestrogen and subsequently with gonadotrophins and testosterone. Andrologia. 1999 Jul;31(4):225-31. PubMed PMID: 10470413. 8: Bachmann S, Hellwig J, Jäckh R, Christian MS. Uterotrophic assay of two concentrations of migrates from each of 23 polystyrenes administered orally (by gavage) to immature female Wistar rats. Drug Chem Toxicol. 1998;21 Suppl 1:1-30. PubMed PMID: 10028402. 9: Goy RW, Deputte BL. The effects of diethylstilbestrol (DES) before birth on the development of masculine behavior in juvenile female rhesus monkeys. Horm Behav. 1996 Dec;30(4):379-86. Erratum in: Horm Behav 1997 Aug;32(1):69. PubMed PMID: 9047264. 10: Weijman J, Zwart P, Vos JG, Ramaekers FC. Immunohistochemical method for detecting lesions in the prostate gland of bulls treated with diethylstilbestrol-dipropionate. Vet Rec. 1996 Nov 23;139(21):515-9. PubMed PMID: 8953692. 11: Migliore L, Cocchi L, Scarpato R. Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens. Mutagenesis. 1996 May;11(3):285-90. PubMed PMID: 8671750. 12: Gibson DP, Aardema MJ, Kerckaert GA, Carr GJ, Brauninger RM, LeBoeuf RA. Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay. Mutat Res. 1995 May;343(1):7-24. PubMed PMID: 7753109. 13: Singh S, Guraya SS. Follicular growth patterns in the house rat (Rattus rattus). Eur J Morphol. 1993 Dec;31(4):257-65. PubMed PMID: 8172756. 14: Albertini S, Brunner M, Würgler FE. Analysis of the six additional chemicals for in vitro assays of the European Economic Communities' EEC aneuploidy programme using Saccharomyces cerevisiae D61.M and the in vitro porcine brain tubulin assembly assay. Environ Mol Mutagen. 1993;21(2):180-92. PubMed PMID: 8444145. 15: Martinez-Azorin F, Teruel JA, Fernandez-Belda F, Gomez-Fernandez JC. Effect of diethylstilbestrol and related compounds on the Ca(2+)-transporting ATPase of sarcoplasmic reticulum. J Biol Chem. 1992 Jun 15;267(17):11923-9. PubMed PMID: 1318306. 16: Weijman J, Ramaekers FC, Elsinghorst TA, van Wichen PJ, Zwart P. Changing cytokeratin expression patterns in diethylstilbestrol dipropionate-induced metaplastic lesions of the goat prostate. Vet Q. 1992 Jan;14(1):2-7. PubMed PMID: 1374200. 17: Bernhardt G, Reile H, Birnböck H, Spruss T, Schönenberger H. Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity. J Cancer Res Clin Oncol. 1992;118(1):35-43. PubMed PMID: 1309532. 18: Buresová A, Bártová D, Svestka J. Comparison of pharmacotherapeutic procedures in the treatment of sexual deviant behaviour. Act Nerv Super (Praha). 1990 Dec;32(4):299-301. PubMed PMID: 1982035. 19: Whittaker SG, Zimmermann FK, Dicus B, Piegorsch WW, Resnick MA, Fogel S. Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae--an interlaboratory assessment of 12 chemicals. Mutat Res. 1990 Jul;241(3):225-42. PubMed PMID: 2195333. 20: Bordiushkov IuN, Kuz'menko VN, Kirsanova LD. [The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid]. Probl Endokrinol (Mosk). 1990 Jan-Feb;36(1):69-72. Russian. PubMed PMID: 2109865.