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MedKoo Cat#: 598343 | Name: Trametenolic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trametenolic acid is the main active composition of Trametes lactinea Pat which possesses antitumor activities.

Chemical Structure

Trametenolic acid
Trametenolic acid
CAS#24160-36-9

Theoretical Analysis

MedKoo Cat#: 598343

Name: Trametenolic acid

CAS#: 24160-36-9

Chemical Formula: C30H48O3

Exact Mass: 456.3603

Molecular Weight: 456.71

Elemental Analysis: C, 78.90; H, 10.59; O, 10.51

Price and Availability

Size Price Availability Quantity
5mg USD 750.00 2 Weeks
10mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Trametenolic acid; (+)-trametenolic acid B;
IUPAC/Chemical Name
(R)-2-((3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-enoic acid
InChi Key
NBSBUIQBEPROBM-GIICLEHTSA-N
InChi Code
InChI=1S/C30H48O3/c1-19(2)9-8-10-20(26(32)33)21-13-17-30(7)23-11-12-24-27(3,4)25(31)15-16-28(24,5)22(23)14-18-29(21,30)6/h9,20-21,24-25,31H,8,10-18H2,1-7H3,(H,32,33)/t20-,21-,24+,25+,28-,29-,30+/m1/s1
SMILES Code
CC1(C)[C@@H](O)CC[C@]2(C)C3=C([C@@]4(CC[C@@H]([C@]4(CC3)C)[C@H](C(O)=O)CC/C=C(C)\C)C)CC[C@@]12[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 456.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Q, Wang J, He H, Liu H, Yan X, Zou K. Trametenolic acid B reverses multidrug resistance in breast cancer cells through regulating the expression level of P-glycoprotein. Phytother Res. 2014 Jul;28(7):1037-44. PubMed PMID: 25289403. 2: Zhang Q, Huang N, Wang J, Luo H, He H, Ding M, Deng WQ, Zou K. The H+/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells. Fitoterapia. 2013 Sep;89:210-7. doi: 10.1016/j.fitote.2013.05.021. Epub 2013 Jun 3. PubMed PMID: 23742858. 3: Du D, Zhu F, Chen X, Ju X, Feng Y, Qi LW, Jiang J. Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection. Phytochem Anal. 2011 Sep-Oct;22(5):419-23. doi: 10.1002/pca.1297. Epub 2011 Mar 24. PubMed PMID: 21433158. 4: Yan ZF, Yang Y, Tian FH, Mao XX, Li Y, Li CT. Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells. Evid Based Complement Alternat Med. 2014;2014:259836. doi: 10.1155/2014/259836. Epub 2014 Aug 13. PubMed PMID: 25197307; PubMed Central PMCID: PMC4145793. 5: Wang W, Dong H, Yan R, Li H, Li P, Chen P, Yang B, Wang Z. Comparative study of lanostane-type triterpene acids in different parts of Poria cocos (Schw.) Wolf by UHPLC-Fourier transform MS and UHPLC-triple quadruple MS. J Pharm Biomed Anal. 2015 Jan;102:203-14. doi: 10.1016/j.jpba.2014.09.014. Epub 2014 Sep 19. PubMed PMID: 25282601. 6: Ma L, Chen H, Dong P, Lu X. Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus. Food Chem. 2013 Aug 15;139(1-4):503-8. doi: 10.1016/j.foodchem.2013.01.030. Epub 2013 Feb 1. PubMed PMID: 23561137. 7: Leliebre-Lara V, Monzote Fidalgo L, Pferschy-Wenzig EM, Kunert O, Nogueiras Lima C, Bauer R. In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden). Molecules. 2016 Aug 10;21(8). pii: E1045. doi: 10.3390/molecules21081045. PubMed PMID: 27517895. 8: Kahlos K, Hiltunen R, V Schantz M. 3beta-Hydroxy-lanosta-8,24-dien-21-al, a New Triterpene from Inontus obliquus. Planta Med. 1984 Apr;50(2):197-8. PubMed PMID: 17340294. 9: Quang DN, Hashimoto T, Tanaka M, Asakawa Y. Tyromycic acids F and G: two new triterpenoids from the mushroom Tyromyces fissilis. Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1441-3. PubMed PMID: 14646328. 10: Keller AC, Maillard MP, Hostettmann K. Antimicrobial steroids from the fungus Fomitopsis pinicola. Phytochemistry. 1996 Mar;41(4):1041-6. PubMed PMID: 8728714. 11: Lu X, Chen H, Dong P, Fu L, Zhang X. Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. J Sci Food Agric. 2010 Jan 30;90(2):276-80. doi: 10.1002/jsfa.3809. PubMed PMID: 20355042. 12: Zhao F, Mai Q, Ma J, Xu M, Wang X, Cui T, Qiu F, Han G. Triterpenoids from Inonotus obliquus and their antitumor activities. Fitoterapia. 2015 Mar;101:34-40. doi: 10.1016/j.fitote.2014.12.005. Epub 2014 Dec 24. PubMed PMID: 25542686. 13: Nakata T, Yamada T, Taji S, Ohishi H, Wada S, Tokuda H, Sakuma K, Tanaka R. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007 Jan 1;15(1):257-64. Epub 2006 Sep 30. PubMed PMID: 17049251. 14: Zheng WF, Liu T, Xiang XY, Gu Q. Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. Yao Xue Xue Bao. 2007 Jul;42(7):750-6. PubMed PMID: 17882960. 15: Lee SR, Lee S, Moon E, Park HJ, Park HB, Kim KH. Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorg Chem. 2017 Feb;70:94-99. doi: 10.1016/j.bioorg.2016.11.012. Epub 2016 Nov 23. PubMed PMID: 27912907. 16: Zan JF, Shen CJ, Zhang LP, Liu YW. Effect of Poria cocos hydroethanolic extract on treating adriamycin-induced rat model of nephrotic syndrome. Chin J Integr Med. 2017 Dec;23(12):916-922. doi: 10.1007/s11655-016-2643-6. Epub 2016 Dec 29. PubMed PMID: 28035538. 17: Shi ZT, Bao HY, Feng S. [Antitumor activity and structure-activity relationship of seven lanostane-type triterpenes from Fomitopsis pinicola and F. officinalis]. Zhongguo Zhong Yao Za Zhi. 2017 Mar;42(5):915-922. doi: 10.19540/j.cnki.cjcmm.20170121.017. Chinese. PubMed PMID: 28994535. 18: Li S, Zhang J, Li S, Liu C, Liu S, Liu Z. Extraction and separation of lactate dehydrogenase inhibitors from Poria cocos (Schw.) Wolf based on a hyphenated technique and in vitro methods. J Sep Sci. 2017 Apr;40(8):1773-1783. doi: 10.1002/jssc.201700054. Epub 2017 Mar 17. PubMed PMID: 28217983. 19: Baek J, Roh HS, Baek KH, Lee S, Lee S, Song SS, Kim KH. Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells. J Ethnopharmacol. 2018 May 22;224:63-75. doi: 10.1016/j.jep.2018.05.025. [Epub ahead of print] PubMed PMID: 29800742.