MedKoo Cat#: 556139 | Name: FHN88734
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FHN88734, also known as Z-Asp-CH2-DCB and PASE-1 INHIBITOR V, is an inhibitor of ICE/Ced-3 family proteases. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

FHN88734
FHN88734
CAS#153088-73-4

Theoretical Analysis

MedKoo Cat#: 556139

Name: FHN88734

CAS#: 153088-73-4

Chemical Formula: C20H17Cl2NO7

Exact Mass: 453.0382

Molecular Weight: 454.26

Elemental Analysis: C, 52.88; H, 3.77; Cl, 15.61; N, 3.08; O, 24.65

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
200mg USD 2,950.00 2 Weeks
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Related CAS #
No Data
Synonym
Z-Asp-CH2-DCB; PASE-1 Inhibitor V; FHN88734; FHN-88734; FHN 88734;
IUPAC/Chemical Name
(S)-3-(((benzyloxy)carbonyl)amino)-5-((2,6-dichlorobenzoyl)oxy)-4-oxopentanoic acid
InChi Key
FKJMFCOMZYPWCO-HNNXBMFYSA-N
InChi Code
InChI=1S/C20H17Cl2NO7/c21-13-7-4-8-14(22)18(13)19(27)29-11-16(24)15(9-17(25)26)23-20(28)30-10-12-5-2-1-3-6-12/h1-8,15H,9-11H2,(H,23,28)(H,25,26)/t15-/m0/s1
SMILES Code
ClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Krakauer T. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4. doi: 10.1128/CDLI.11.3.621-624.2004. PMID: 15138192; PMCID: PMC404582. 2. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9. doi: 10.1172/JCI10259. PMID: 11104784; PMCID: PMC387249. 3. Twumasi P, Iakimova ET, Qian T, van Ieperen W, Schel JH, Emons AM, van Kooten O, Woltering EJ. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162. doi: 10.1186/1471-2229-10-162. PMID: 20691058; PMCID: PMC3017784.