MedKoo Cat#: 526180 | Name: Ro 24-6392

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 24-6392 is a novel ester-linked co-drug combining ciprofloxacin and desacetylcefotaxime. Ro 24-6392 demonstrats activity against a wide spectrum of aerobic bacteria, 98.6% of strains being inhibited by less than or equal to 8 mg/l.

Chemical Structure

Ro 24-6392
Ro 24-6392
CAS#131149-63-8

Theoretical Analysis

MedKoo Cat#: 526180

Name: Ro 24-6392

CAS#: 131149-63-8

Chemical Formula: C31H31FN8O8S2

Exact Mass: 726.1690

Molecular Weight: 726.76

Elemental Analysis: C, 51.23; H, 4.30; F, 2.61; N, 15.42; O, 17.61; S, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 24-6392; Ro-24-6392; Ro 246392.
IUPAC/Chemical Name
(6R,7R)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carbonyl)oxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key
MPWTZPXSZLWXHL-LJPPBSFJSA-N
InChi Code
InChI=1S/C31H31FN8O8S2/c1-47-37-22(19-13-50-31(33)35-19)26(42)36-23-27(43)40-24(29(44)45)14(12-49-28(23)40)11-48-30(46)17-10-39(15-2-3-15)20-9-21(38-6-4-34-5-7-38)18(32)8-16(20)25(17)41/h8-10,13,15,23,28,34H,2-7,11-12H2,1H3,(H2,33,35)(H,36,42)(H,44,45)/b37-22+/t23-,28-/m1/s1
SMILES Code
O=C(C(N12)=C(COC(C3=CN(C4CC4)C5=C(C=C(F)C(N6CCNCC6)=C5)C3=O)=O)CS[C@]2([H])[C@H](NC(/C(C7=CSC(N)=N7)=N/OC)=O)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 726.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Georgopapadakou NH, Bertasso A. Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob Agents Chemother. 1993 Mar;37(3):559-65. PubMed PMID: 8384817; PubMed Central PMCID: PMC187707. 2: Jones RN. In vitro activity of Ro 24-6392, a novel ester-linked co-drug combining ciprofloxacin and desacetylcefotaxime. Eur J Clin Microbiol Infect Dis. 1990 Jun;9(6):435-8. PubMed PMID: 2387298.