Ipsalazide | CAS#80573-03-1 | sulfasalazine analog

MedKoo Cat#: 563204 | Name: Ipsalazide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ipsalazide is a sulfasalazine analog. It acts by releasing 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

Chemical Structure

Ipsalazide

CAS#80573-03-1

Theoretical Analysis

MedKoo Cat#: 563204

Name: Ipsalazide

CAS#: 80573-03-1

Chemical Formula: C16H13N3O6

Exact Mass: 343.0804

Molecular Weight: 343.29

Elemental Analysis: C, 55.98; H, 3.82; N, 12.24; O, 27.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ipsalazide; BX-650A; BX 650A; BX650A; BX 650 A; BX-650-A;

IUPAC/Chemical Name

(E)-3-(2-(4-((carboxymethyl)carbamoyl)phenyl)hydrazono)-6-oxocyclohexa-1,4-diene-1-carboxylic acid

InChi Key

XZNVCJQXBZGVHJ-YBFXNURJSA-N

InChi Code

InChI=1S/C16H13N3O6/c20-13-6-5-11(7-12(13)16(24)25)19-18-10-3-1-9(2-4-10)15(23)17-8-14(21)22/h1-7,18H,8H2,(H,17,23)(H,21,22)(H,24,25)/b19-11+

SMILES Code

O=C(NCC(O)=O)C1=CC=C(N/N=C2C=C(C(O)=O)C(C=C/2)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dhaneshwar SS. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. World J Gastroenterol. 2014 Apr 7;20(13):3564-71. doi: 10.3748/wjg.v20.i13.3564. Review. PubMed PMID: 24707139; PubMed Central PMCID: PMC3974523. 2: Reddy SM, Sinha VR, Reddy DS. Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs. Drugs Today (Barc). 1999 Jul;35(7):537-80. PubMed PMID: 12973398. 3: Klotz U. Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid. Clin Pharmacokinet. 1985 Jul-Aug;10(4):285-302. Review. PubMed PMID: 2864155. 4: Chan RP, Pope DJ, Gilbert AP, Sacra PJ, Baron JH, Lennard-Jones JE. Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. Dig Dis Sci. 1983 Jul;28(7):609-15. PubMed PMID: 6345112.