MCC1019 | CAS#29115-34-2 | PLK1 Polo-box domain inhibitor

MedKoo Cat#: 463421 | Name: MCC1019

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MCC1019 is a novel selective inhibitor of the Polo-box domain of Polo-like kinase 1 (PLK1).

Chemical Structure

MCC1019

CAS#29115-34-2

Theoretical Analysis

MedKoo Cat#: 463421

Name: MCC1019

CAS#: 29115-34-2

Chemical Formula: C12H11BrO3

Exact Mass: 281.9892

Molecular Weight: 283.12

Elemental Analysis: C, 50.91; H, 3.92; Br, 28.22; O, 16.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MCC1019; MCC-1019; MCC 1019;

IUPAC/Chemical Name

ethyl 3-(bromomethyl)benzofuran-2-carboxylate

InChi Key

AHTASHQCOAXTTF-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H11BrO3/c1-2-15-12(14)11-9(7-13)8-5-3-4-6-10(8)16-11/h3-6H,2,7H2,1H3

SMILES Code

O=C(C1=C(CBr)C2=CC=CC=C2O1)OCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 283.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Abdelfatah S, Berg A, Huang Q, Yang LJ, Hamdoun S, Klinger A, Greten HJ, Fleischer E, Berg T, Wong VKW, Efferth T. MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate. Acta Pharm Sin B. 2019 Sep;9(5):1021-1034. doi: 10.1016/j.apsb.2019.02.001. Epub 2019 Feb 10. PMID: 31649851; PMCID: PMC6804483.