Elisidepsin TFA | CAS#915713-02-9 | antineoplastic

MedKoo Cat#: 598117 | Name: Elisidepsin TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Elisidepsin, also known as PM 02734, is a synthetic marine-derived cyclic peptide of the Kahalalide F. Elisidepsin was shown to induce rapid oncosis in ErbB3-expressing cells. Elisidepsin showed potent and broad cytotoxic effects in our cancer cell line panel, being active at concentrations ranging from 0.4 to 2 μM that may be relevant for clinical settings. Elisidepsin is more active in cells harboring epithelial phenotype with high E-cadherin and low vimentin expression.

Chemical Structure

Elisidepsin TFA

CAS#915713-02-9 (TFA)

Theoretical Analysis

MedKoo Cat#: 598117

Name: Elisidepsin TFA

CAS#: 915713-02-9 (TFA)

Chemical Formula: C77H125F3N14O18

Exact Mass: 1590.9248

Molecular Weight: 1591.92

Elemental Analysis: C, 58.10; H, 7.91; F, 3.58; N, 12.32; O, 18.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

681272-30-0 (free base) 915713-02-9 (TFA)

Synonym

PM 02734; PM-02734; PM02734; Elisidepsin; Irvalec; Isokahalalide F; Elisidepsin TFA;

IUPAC/Chemical Name

(R)-N-((S)-5-amino-1-(((2R,3S)-1-(((3S,9S,12R,15R,18R,19R,Z)-9-benzyl-15-((S)-sec-butyl)-6-ethylidene-3,12-diisopropyl-19-methyl-2,5,8,11,14,17-hexaoxo-1-oxa-4,7,10,13,16-pentaazacyclononadecan-18-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)-1-(((S)-4-methylhexanoyl)-D-valyl-L-threonyl-L-valyl-D-valyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

InChi Key

FUDHRLIJYPGBOX-MWGCIELCSA-N

InChi Code

InChI=1S/C75H124N14O16.C2HF3O2/c1-20-43(15)33-34-53(91)80-54(38(5)6)68(97)87-61(46(18)90)72(101)82-56(40(9)10)69(98)83-57(41(11)12)74(103)89-36-28-32-52(89)66(95)78-50(31-27-35-76)64(93)85-59(44(16)21-2)71(100)88-62-47(19)105-75(104)58(42(13)14)84-63(92)49(23-4)77-65(94)51(37-48-29-25-24-26-30-48)79-67(96)55(39(7)8)81-70(99)60(45(17)22-3)86-73(62)102;3-2(4,5)1(6)7/h23-26,29-30,38-47,50-52,54-62,90H,20-22,27-28,31-37,76H2,1-19H3,(H,77,94)(H,78,95)(H,79,96)(H,80,91)(H,81,99)(H,82,101)(H,83,98)(H,84,92)(H,85,93)(H,86,102)(H,87,97)(H,88,100);(H,6,7)/b49-23-;/t43-,44-,45-,46+,47+,50-,51-,52+,54+,55+,56-,57+,58-,59+,60+,61-,62+;/m0./s1

SMILES Code

CC[C@@H](CCC(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N1CCC[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@@H]2[C@H](OC([C@H](C(C)C)NC(/C(NC([C@@H](NC([C@@H](C(C)C)NC([C@@H]([C@H](CC)C)NC2=O)=O)=O)Cc3ccccc3)=O)=C/C)=O)=O)C)=O)[C@H](CC)C)=O)CCCN)=O)=O)C(C)C)=O)C(C)C)=O)[C@H](O)C)=O)C(C)C)=O)C.OC(C(F)(F)F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,591.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.