MedKoo Cat#: 558400 | Name: ALC67

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALC67 is a N-acylated thiazolidine compound with promising anticancer activity that led to the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of caspase-9 involved apoptotic pathway, which is death receptor independent.

Chemical Structure

ALC67
ALC67
CAS#1044255-57-3

Theoretical Analysis

MedKoo Cat#: 558400

Name: ALC67

CAS#: 1044255-57-3

Chemical Formula: C15H15NO3S

Exact Mass: 289.0800

Molecular Weight: 289.35

Elemental Analysis: C, 62.27; H, 5.23; N, 4.84; O, 16.59; S, 11.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ALC67; ALC-67; ALC 67;
IUPAC/Chemical Name
(2RS, 4R)-2-Phenyl-3-propynoyl-thiazolidine-4-carboxylic acid ethyl ester
InChi Key
VYDZOJXGXGQPPY-NBFOIZRFSA-N
InChi Code
InChI=1S/C15H15NO3S/c1-3-13(17)16-12(15(18)19-4-2)10-20-14(16)11-8-6-5-7-9-11/h1,5-9,12,14H,4,10H2,2H3/t12-,14?/m0/s1
SMILES Code
O=C([C@H]1N(C(C#C)=O)C(C2=CC=CC=C2)SC1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 289.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Charehsaz M, Onen-Bayram FE, Sipahi H, Buran K, Giri AK, Aydin A. Evaluation of the mutagenic and genotoxic effects of the ALC67 thiazolidine compound in Salmonella strains and human lymphocytes in vitro. Hum Exp Toxicol. 2016 Oct;35(10):1108-15. doi: 10.1177/0960327115621365. Epub 2015 Dec 13. PubMed PMID: 26666987. 2: Onen-Bayram FE, Durmaz I, Scherman D, Herscovici J, Cetin-Atalay R. A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells. Bioorg Med Chem. 2012 Sep 1;20(17):5094-102. doi: 10.1016/j.bmc.2012.07.016. Epub 2012 Jul 20. PubMed PMID: 22867707.