CYM50358 HCl | CAS#1781750-72-8 | S1P4 antagonist

MedKoo Cat#: 563250 | Name: CYM50358 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CYM50358 HCl is a selective S1P4 antagonist.

Chemical Structure

CYM50358 HCl

CAS#1781750-72-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 563250

Name: CYM50358 HCl

CAS#: 1781750-72-8 (HCl)

Chemical Formula: C20H19Cl3N2O2

Exact Mass: 424.0512

Molecular Weight: 425.73

Elemental Analysis: C, 56.42; H, 4.50; Cl, 24.98; N, 6.58; O, 7.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1314212-39-9 (free base) 1781750-72-8 (HCl)

Synonym

CYM50358 HCl; CYM-50358 HCl; CYM 50358 HCl; CYM50358 hydrochloride; CYM-50358 hydrochloride; CYM 50358 hydrochloride;

IUPAC/Chemical Name

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide hydrochloride

InChi Key

OFDSTJOMVDAKCS-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H18Cl2N2O2.ClH/c1-11-7-13(10-23)8-12(2)19(11)24-20(25)18-6-5-17(26-18)15-9-14(21)3-4-16(15)22;/h3-9H,10,23H2,1-2H3,(H,24,25);1H

SMILES Code

NCC1=CC(C)=C(NC(C2=CC=C(C3=CC(Cl)=CC=C3Cl)O2)=O)C(C)=C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 425.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Onuma T, Tanabe K, Kito Y, Tsujimoto M, Uematsu K, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100. doi: 10.1016/j.thromres.2017.06.001. Epub 2017 Jun 2. PubMed PMID: 28609704. 2: Cencetti F, Bernacchioni C, Tonelli F, Roberts E, Donati C, Bruni P. TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 2013 Nov;27(11):4532-46. doi: 10.1096/fj.13-228528. Epub 2013 Aug 2. PubMed PMID: 23913862.