VU625 | CAS#901008-62-6 | potassium channel inhibitor

MedKoo Cat#: 562710 | Name: VU625

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU625 is a potent and selective inhibitor of aedes aegypti inward rectifier potassium channels.

Chemical Structure

VU625

CAS#901008-62-6

Theoretical Analysis

MedKoo Cat#: 562710

Name: VU625

CAS#: 901008-62-6

Chemical Formula: C19H22N2O4S

Exact Mass: 374.1300

Molecular Weight: 374.45

Elemental Analysis: C, 60.94; H, 5.92; N, 7.48; O, 17.09; S, 8.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VU625; VU-625; VU 625; VU007625; VU-007625; VU 007625;

IUPAC/Chemical Name

2,3-Dihydro-N-(3-methoxyphenyl)-2-methyl-1-(1-oxopropyl)-1H-indole-5-sulfonamide

InChi Key

VUYMDHNPCUZQDK-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H22N2O4S/c1-4-19(22)21-13(2)10-14-11-17(8-9-18(14)21)26(23,24)20-15-6-5-7-16(12-15)25-3/h5-9,11-13,20H,4,10H2,1-3H3

SMILES Code

O=S(C1=CC2=C(N(C(CC)=O)C(C)C2)C=C1)(NC3=CC=CC(OC)=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Beyenbach KW, Yu Y, Piermarini PM, Denton J. Targeting renal epithelial channels for the control of insect vectors. Tissue Barriers. 2015 Sep 1;3(4):e1081861. doi: 10.1080/21688370.2015.1081861. eCollection 2015 Oct-Dec. Review. PubMed PMID: 26716074; PubMed Central PMCID: PMC4681290. 2: Piermarini PM, Dunemann SM, Rouhier MF, Calkins TL, Raphemot R, Denton JS, Hine RM, Beyenbach KW. Localization and role of inward rectifier K(+) channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti. Insect Biochem Mol Biol. 2015 Dec;67:59-73. doi: 10.1016/j.ibmb.2015.06.006. Epub 2015 Jun 12. PubMed PMID: 26079629. 3: Raphemot R, Rouhier MF, Swale DR, Days E, Weaver CD, Lovell KM, Konkel LC, Engers DW, Bollinger SR, Hopkins C, Piermarini PM, Denton JS. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. PLoS One. 2014 Nov 6;9(11):e110772. doi: 10.1371/journal.pone.0110772. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119883. Bollinger, Sean F [corrected to Bollinger, Sean R]. PubMed PMID: 25375326; PubMed Central PMCID: PMC4222822.