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MedKoo Cat#: 597416 | Name: SQ 32970

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SQ 32970 is a potent inhibitor of Endothia aspartic proteinase.

Chemical Structure

SQ 32970
SQ 32970
CAS#122280-12-0

Theoretical Analysis

MedKoo Cat#: 597416

Name: SQ 32970

CAS#: 122280-12-0

Chemical Formula: C33H51N5O4S

Exact Mass: 613.3662

Molecular Weight: 613.86

Elemental Analysis: C, 64.57; H, 8.37; N, 11.41; O, 10.43; S, 5.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SQ 32970; SQ-32970; SQ32970; SQ-32,970; SQ 32,970; SQ32,970;
IUPAC/Chemical Name
6-amino-N-((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)((1R,2S)-3-cyclohexyl-1-hydroxy-1-(thiazol-2-yl)propan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)hexanamide
InChi Key
NCXMNZCLHCPEEE-VNDOHOEKSA-N
InChi Code
InChI=1S/C33H51N5O4S/c1-23(2)20-28(31(35)41)38(27(22-25-14-8-4-9-15-25)30(40)32-36-18-19-43-32)33(42)26(21-24-12-6-3-7-13-24)37-29(39)16-10-5-11-17-34/h3,6-7,12-13,18-19,23,25-28,30,40H,4-5,8-11,14-17,20-22,34H2,1-2H3,(H2,35,41)(H,37,39)/t26-,27-,28-,30+/m0/s1
SMILES Code
CC(C)C[C@@H](C(N)=O)N(C([C@H](CC1=CC=CC=C1)NC(CCCCCN)=O)=O)[C@@H](CC2CCCCC2)[C@@H](O)C3=NC=CS3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 613.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Norman JA, Little D, Free CA, Dejneka T, Weber H, Ryono DE. Affinity purification of endothia protease with a novel renin inhibitor SQ 32,970. Biochem Biophys Res Commun. 1989 May 30;161(1):1-7. PubMed PMID: 2658996. 2: Norman JA, Hadjilambris O, Baska R, Sharp DY, Kumar R. Stable expression, secretion, and characterization of active human renin in mammalian cells. Mol Pharmacol. 1992 Jan;41(1):53-9. PubMed PMID: 1732722.