Cefetamet Hydrochloride | CAS#724438-16-8 | CAS#65052-63-3 | Cephalosporin Antibiotic

MedKoo Cat#: 527513 | Name: Cefetamet Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefetamet Hydrochloride is a cephalosporin antibiotic potentially for the treatment of bacterial infections. Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections. To improve oral bioavailability, it is administered as a prodrug, cefetamet pivoxyl hydrolyzed by esterase following absorption.

Chemical Structure

Cefetamet Hydrochloride

CAS#724438-16-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 527513

Name: Cefetamet Hydrochloride

CAS#: 724438-16-8 (HCl)

Chemical Formula: C14H16ClN5O5S2

Exact Mass: 0.0000

Molecular Weight: 433.88

Elemental Analysis: C, 38.76; H, 3.72; Cl, 8.17; N, 16.14; O, 18.44; S, 14.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

724438-16-8 (HCl) 65052-63-3 (free base) 65243-25-6 (sodium) 65243-33-6 (pivoxil)

Synonym

Cefetamet Hydrochloride; Cefetamet HCl; Cefetamet

IUPAC/Chemical Name

(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride

InChi Key

KILIJEXWGYQTDT-KYIYMPJCSA-N

InChi Code

InChI=1S/C14H15N5O5S2.ClH/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6;/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23);1H/b18-7-;/t8-,12-;/m1./s1

SMILES Code

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Garbacki P, Cielecka-Piontek J, Zalewski P, Oszczapowicz I, Jelińska A. A SIMPLE AND-SENSITIVE STABILITY-INDICATING UHPLC-DAD METHOD FOR THE DETERMINATION OF CEFETAMET PIVOXIL HYDROCHLORIDE. Acta Pol Pharm. 2016 May-Jun;73(3):621-6. PubMed PMID: 27476279. 2: Wang D, Wang F, Wang J. Characterization of the impurities and isomers in cefetamet pivoxil hydrochloride by liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry. J Pharm Biomed Anal. 2015;111:71-7. doi: 10.1016/j.jpba.2015.03.013. PubMed PMID: 25863019. 3: Vadia NH, Patel V, Bhalara HN. Spectrophotometric Determination of Cefetamet Pivoxil Hydrochloride and Pitavastatin Calcium in Tablet Dosage form. Indian J Pharm Sci. 2008 Sep;70(5):649-51. doi: 10.4103/0250-474X.45408. PubMed PMID: 21394266; PubMed Central PMCID: PMC3038294. 4: Sateesha S, Rajamma A, Shekar H, Divakar G. Formulation development and rheological studies of palatable cefetamet pivoxil hydrochloride dry powder suspension. Daru. 2011;19(2):118-25. PubMed PMID: 22615648; PubMed Central PMCID: PMC3232094. 5: Jelińska A, Dobrowolski L, Oszczapowicz I. The influence of pH, temperature and buffers on the degradation kinetics of cefetamet pivoxil hydrochloride in aqueous solutions. J Pharm Biomed Anal. 2004 Sep 3;35(5):1273-7. PubMed PMID: 15336372. 6: Jelińska A, Zajac M, Dobrowolski L, Medenecka B, Ruciński P, Oszczapowicz I. Kinetics of degradation of cefetamet pivaloyloxymethyl ester and its hydrochloride in solid phase. Acta Pol Pharm. 2003 Nov-Dec;60(6):435-41. PubMed PMID: 15080590. 7: Morsch LM, Bittencourt CF, e Souza MJ, Milano J. LC method for the analysis of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension. J Pharm Biomed Anal. 2002 Oct 15;30(3):643-49. PubMed PMID: 12367689. 8: Du J, Li H. Sensitive chemiluminescence determination of thirteen cephalosporin antibiotics with luminol-copper(II) reaction. Appl Spectrosc. 2010 Oct;64(10):1154-9. doi: 10.1366/000370210792973613. PubMed PMID: 20925986. 9: Cazzola M. Novel oral cephalosporins. Expert Opin Investig Drugs. 2000 Feb;9(2):237-46. Review. PubMed PMID: 11060674. 10: Noh K, Kim E, Kang W. Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry. Biomed Chromatogr. 2011 Jul;25(7):779-82. doi: 10.1002/bmc.1516. PubMed PMID: 20845371.