Synonym
Cefetamet sodium; Ro 15-8074/001; Ro-15-8074/001; Ro15-8074/001;
IUPAC/Chemical Name
sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
NZQJSIPYDOTDFS-KYIYMPJCSA-M
InChi Code
InChI=1S/C14H15N5O5S2.Na/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6;/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23);/q;+1/p-1/b18-7-;/t8-,12-;/m1./s1
SMILES Code
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)[O-].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
419.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li CZ, Sun JY, Wang Y, Qin YP, Miao J. [Phase I clinical trial on the safety of injectable cefetamet sodium with a single dose in healthy volunteers]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;45(4):637-41. Chinese. PubMed PMID: 25286691.
2: Li C, Sun J, Miao J, Qin Y, Wang Y, Yu R, Xiao Y. Using Monte Carlo simulation to determine optimal dosing regimen for cefetamet sodium for injection. J Chemother. 2016 Jun;28(3):172-9. doi: 10.1179/1973947814Y.0000000214. PubMed PMID: 25252727.
3: Wyss R, Bucheli F. Determination of cefetamet and its orally active ester, cefetamet pivoxyl, in biological fluids by high-performance liquid chromatography. J Chromatogr. 1988 Aug 19;430(1):81-92. PubMed PMID: 3215964.
4: Garbacki P, Cielecka-Piontek J, Zalewski P, Oszczapowicz I, Jelińska A. A SIMPLE AND-SENSITIVE STABILITY-INDICATING UHPLC-DAD METHOD FOR THE DETERMINATION OF CEFETAMET PIVOXIL HYDROCHLORIDE. Acta Pol Pharm. 2016 May-Jun;73(3):621-6. PubMed PMID: 27476279.
5: Sateesha S, Rajamma A, Shekar H, Divakar G. Formulation development and rheological studies of palatable cefetamet pivoxil hydrochloride dry powder suspension. Daru. 2011;19(2):118-25. PubMed PMID: 22615648; PubMed Central PMCID: PMC3232094.
6: Du J, Li H. Sensitive chemiluminescence determination of thirteen cephalosporin antibiotics with luminol-copper(II) reaction. Appl Spectrosc. 2010 Oct;64(10):1154-9. doi: 10.1366/000370210792973613. PubMed PMID: 20925986.
