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MedKoo Cat#: 564492 | Name: CM304

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM304 is a highly selective sigma-1 receptor antagonist.

Chemical Structure

CM304
CM304
CAS#1417742-48-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 564492

Name: CM304

CAS#: 1417742-48-3 (HCl)

Chemical Formula: C18H26ClFN2OS

Exact Mass: 372.1438

Molecular Weight: 372.93

Elemental Analysis: C, 57.97; H, 7.03; Cl, 9.51; F, 5.09; N, 7.51; O, 4.29; S, 8.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1350296-21-7 (free base) 1417742-48-3 (HCl)
Synonym
CM-304; CM 304; CM304
IUPAC/Chemical Name
3-(2-(Azepan-1-yl)ethyl)-6-(3-fluoropropyl)benzo[d]thiazol-2(3H)-one hydrochloride
InChi Key
IAHXPDSLCDRWPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H25FN2OS.ClH/c19-9-5-6-15-7-8-16-17(14-15)23-18(22)21(16)13-12-20-10-3-1-2-4-11-20;/h7-8,14H,1-6,9-13H2;1H
SMILES Code
O=C1SC2=CC(CCCF)=CC=C2N1CCN3CCCCCC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 372.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL. The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. J Biol Chem. 2017 Jul 7;292(27):11250-11261. doi: 10.1074/jbc.M116.774075. Epub 2017 May 11. PubMed PMID: 28495886; PubMed Central PMCID: PMC5500793. 2: Avery BA, Vuppala PK, Jamalapuram S, Sharma A, Mesangeau C, Chin FT, McCurdy CR. Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study. Drug Test Anal. 2017 Aug;9(8):1236-1242. doi: 10.1002/dta.2156. Epub 2017 Apr 11. PubMed PMID: 28039926.