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MedKoo Cat#: 584240 | Name: BO 1165

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BO 1165 is a new monobactam antibiotic.

Chemical Structure

BO 1165
BO 1165
CAS#89426-64-2

Theoretical Analysis

MedKoo Cat#: 584240

Name: BO 1165

CAS#: 89426-64-2

Chemical Formula: C13H14FN5O8S2

Exact Mass: 451.0268

Molecular Weight: 451.40

Elemental Analysis: C, 34.59; H, 3.13; F, 4.21; N, 15.52; O, 28.35; S, 14.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BO 1165; BO1165; BO-1165
IUPAC/Chemical Name
Cyclopropanecarboxylic acid, 1-(((1-(2-amino-4-thiazolyl)-2-((2-(fluoromethyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-, (2R-(2alpha,3beta(Z)))-
InChi Key
VOGCYJSPKJJBEE-CRDTZCLXSA-N
InChi Code
InChI=1S/C13H14FN5O8S2/c14-3-6-8(10(21)19(6)29(24,25)26)17-9(20)7(5-4-28-12(15)16-5)18-27-13(1-2-13)11(22)23/h4,6,8H,1-3H2,(H2,15,16)(H,17,20)(H,22,23)(H,24,25,26)/b18-7-/t6-,8-/m1/s1
SMILES Code
O=C(C1(O/N=C(C2=CSC(N)=N2)\C(N[C@@H]3[C@@H](CF)N(S(=O)(O)=O)C3=O)=O)CC1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 451.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsuda K, Nagashima M, Nakagawa S, Inoue M, Mitsuhashi S. In-vitro antibacterial activity of BO-1165, a new monobactam antibiotic. J Antimicrob Chemother. 1986 Jun;17(6):747-53. PubMed PMID: 3525497. 2: Matsuda K, Sanada M, Nakagawa S, Inoue M, Mitsuhashi S. Preferential hydrolysis of cis configuration compounds at the 3,4 position of monobactams by beta-lactamase from Morganella morganii. Antimicrob Agents Chemother. 1991 Mar;35(3):458-61. PubMed PMID: 2039196; PubMed Central PMCID: PMC245032. 3: Neu HC, Chin NX. In vitro activity and beta-lactamase stability of a new monobactam, B0-1165. Antimicrob Agents Chemother. 1987 Apr;31(4):505-11. PubMed PMID: 3300528; PubMed Central PMCID: PMC174767.