10-Methyl-10-deazaaminopterin | CAS#80576-77-8 | antitumor

MedKoo Cat#: 597219 | Name: 10-Methyl-10-deazaaminopterin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

10-Methyl-10-deazaaminopterin is a folate analog that exhibits antitumor activity.

Chemical Structure

10-Methyl-10-deazaaminopterin

CAS#80576-77-8

Theoretical Analysis

MedKoo Cat#: 597219

Name: 10-Methyl-10-deazaaminopterin

CAS#: 80576-77-8

Chemical Formula: C21H23N7O5

Exact Mass: 453.1761

Molecular Weight: 453.45

Elemental Analysis: C, 55.62; H, 5.11; N, 21.62; O, 17.64

Price and Availability

This product was removed for the commercial reasons.

Related CAS #

No Data

Synonym

10-Methyl-10-deazaaminopterin;

IUPAC/Chemical Name

(4-(1-(2,4-diaminopteridin-6-yl)propan-2-yl)benzoyl)-L-glutamic acid

InChi Key

MQISJAZESFPIPJ-SBNLOKMTSA-N

InChi Code

InChI=1S/C21H23N7O5/c1-10(8-13-9-24-18-16(25-13)17(22)27-21(23)28-18)11-2-4-12(5-3-11)19(31)26-14(20(32)33)6-7-15(29)30/h2-5,9-10,14H,6-8H2,1H3,(H,26,31)(H,29,30)(H,32,33)(H4,22,23,24,27,28)/t10?,14-/m0/s1

SMILES Code

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(C(C)CC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: DeGraw JI, Christie PH, Tagawa H, Kisliuk RL, Gaumont Y, Schmid FA, Sirotnak FM. Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. J Med Chem. 1986 Jun;29(6):1056-61. PubMed PMID: 3712374. 2: Sirotnak FM, DeGraw JI, Schmid FA, Goutas LJ, Moccio DM. New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models. Cancer Chemother Pharmacol. 1984;12(1):26-30. PubMed PMID: 6690070. 3: Sirotnak FM, DeGraw JI, Moccio DM, Samuels LL, Goutas LJ. New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties. Cancer Chemother Pharmacol. 1984;12(1):18-25. PubMed PMID: 6690069.