MedKoo Cat#: 600138 | Name: Ganoderic Acid A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition. (Source: http://en.wikipedia.org/wiki/Ganoderic_acid).

Chemical Structure

Ganoderic Acid A
Ganoderic Acid A
CAS#81907-62-2

Theoretical Analysis

MedKoo Cat#: 600138

Name: Ganoderic Acid A

CAS#: 81907-62-2

Chemical Formula: C30H44O7

Exact Mass: 516.3087

Molecular Weight: 516.67

Elemental Analysis: C, 69.74; H, 8.58; O, 21.68

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
25mg USD 950.00 2 Weeks
50mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Ganoderic-acid-A; Ganoderic Acid A
IUPAC/Chemical Name
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
InChi Key
DYOKDAQBNHPJFD-JNTBEZBXSA-N
InChi Code
InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
SMILES Code
CC1(C)C(CC[C@]2(C)C3=C([C@@]4([C@@H](O)C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(C[C@@H](C)C(O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO.
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway.
In vitro activity:
The present data indicated that pretreatment with GAA (ganoderic acid A) notably suppressed the mRNA expression of TLR2, TLR4, NLRP3, and caspase-1 induced by H2O2 (Figure 6(a)) in NP (nuceus pulposus) cells. Meanwhile, western blot analysis showed that GAA could significantly inhibit the expressions of these proteins (Figure 6(b)). Thus, TLR4/NLRP3 signaling pathway activation induced by H2O2 could be attenuated by GAA. Reference: Bioengineered. 2022 May;13(5):11684-11693. https://pubmed.ncbi.nlm.nih.gov/35506157/
In vivo activity:
Compared to thinning, rupture, and basal layer congestion of gastric mucosa in the gastric and duodenal tissues of the FD (functional dyspepsia) group, the tissues in the GAA (ganoderic acid A) and Dom (domperidone) groups revealed intact gastric structure (Figure 2(a)). In addition, epithelial cell swelling, focal necrosis, exfoliation, and massive inflammatory cell infiltration were seen in the duodenal tissue sections of the FD group. Upon treatment with GAA or Dom, however, these symptoms almost disappeared and only mild hyperemia and inflammatory cell infiltration remained with intact duodenal mucosa (Figure 2(b)). Collectively, GAA could significantly alleviate the gastric and duodenal tissue injury in FD rats. Reference: Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. https://pubmed.ncbi.nlm.nih.gov/35685728/
Solvent mg/mL mM
Solubility
DMSO 5.0 9.68
DMSO 54.5 105.48
Ethanol 51.5 99.68
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 516.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang D, Cai X, Xu F, Kang H, Li Y, Feng R. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 May;13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. PMID: 35506157; PMCID: PMC9275919. 2. Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031-1041. doi: 10.17219/acem/137914. PMID: 34329545. 3. Yang W, Liu R, Zhou L, Chen X, Hu Y. Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia. Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. doi: 10.1155/2022/2298665. PMID: 35685728; PMCID: PMC9173975. 4. Zhu J, Ding J, Li S, Jin J. Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. Exp Ther Med. 2022 Apr;23(4):308. doi: 10.3892/etm.2022.11237. Epub 2022 Feb 24. PMID: 35340879; PMCID: PMC8931630.
In vitro protocol:
1. Wang D, Cai X, Xu F, Kang H, Li Y, Feng R. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 May;13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. PMID: 35506157; PMCID: PMC9275919. 2. Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031-1041. doi: 10.17219/acem/137914. PMID: 34329545.
In vivo protocol:
1. Yang W, Liu R, Zhou L, Chen X, Hu Y. Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia. Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. doi: 10.1155/2022/2298665. PMID: 35685728; PMCID: PMC9173975. 2. Zhu J, Ding J, Li S, Jin J. Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. Exp Ther Med. 2022 Apr;23(4):308. doi: 10.3892/etm.2022.11237. Epub 2022 Feb 24. PMID: 35340879; PMCID: PMC8931630.
1: Yajima Y, Miyazaki M, Okita N, Hoshino T. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. Int J Med Mushrooms. 2013;15(2):175-82. PubMed PMID: 23557369.