MedKoo Cat#: 126757 | Name: CVN293
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively.

Chemical Structure

CVN293
CVN293
CAS#2815296-08-1

Theoretical Analysis

MedKoo Cat#: 126757

Name: CVN293

CAS#: 2815296-08-1

Chemical Formula: C14H10FN7O

Exact Mass: 311.0931

Molecular Weight: 311.28

Elemental Analysis: C, 54.02; H, 3.24; F, 6.10; N, 31.50; O, 5.14

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
CVN293; CVN-293; CVN 293
IUPAC/Chemical Name
4-(7-fluoro-1-(pyridazin-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine
InChi Key
ONRXHVJHFORDDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10FN7O/c15-9-4-1-5-10-12(9)22(7-8-3-2-6-17-19-8)14(18-10)11-13(16)21-23-20-11/h1-6H,7H2,(H2,16,21)
SMILES Code
FC1=C(N(CC2=CC=CN=N2)C(C3=NON=C3N)=N4)C4=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment Roland W. Bürli, Kevin J. Doyle, Louise Dickson, Anna Rowland, Kim Matthews, Andrew J. Stott, Martin Teall, Bernardino Ossola, Samuel G. Russell, Jenna R. M. Harvey, Yiming Wu, Lakshminarayana Narayana, Nicola L. Brice, Mark Carlton, and Lee A. Dawson ACS Medicinal Chemistry Letters Article ASAP DOI: 10.1021/acsmedchemlett.4c00035