MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597206 | Name: Dihydrohomofolic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydrohomofolic acid is a substrate for dihydrofolate reductase; produces tetrahydrohomofolate which in turn inhibits thymidylate synthetase & therefore DNA synthesis.

Chemical Structure

Dihydrohomofolic acid
CAS#14866-11-6

Theoretical Analysis

MedKoo Cat#: 597206

Name: Dihydrohomofolic acid

CAS#: 14866-11-6

Chemical Formula: C20H23N7O6

Exact Mass: 457.1710

Molecular Weight: 457.44

Elemental Analysis: C, 52.51; H, 5.07; N, 21.43; O, 20.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dihydrohomofolic acid;
IUPAC/Chemical Name
(4-((2-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
InChi Key
VEBDSVCWCXWVOS-ZDUSSCGKSA-N
InChi Code
InChI=1S/C20H23N7O6/c21-20-26-16-15(18(31)27-20)24-12(9-23-16)7-8-22-11-3-1-10(2-4-11)17(30)25-13(19(32)33)5-6-14(28)29/h1-4,13,22H,5-9H2,(H,25,30)(H,28,29)(H,32,33)(H4,21,23,26,27,31)/t13-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCCC2=NC3=C(NC(N)=NC3=O)NC2)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mishra LC, Parmar AS, Mead JA. Effect of pretreatment with methotrexate on the reduction of dihydrohomofolic acid in mice. Biochem Pharmacol. 1971 Oct;20(10):2871-8. PubMed PMID: 5114519.