Dihydropteroyl hexaglutamate | CAS#49637-65-2 | critical link

MedKoo Cat#: 597247 | Name: Dihydropteroyl hexaglutamate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydropteroyl hexaglutamate is a critical link binding together sub-structures of the tail of Escherichia coli bacteriophage T4.

Chemical Structure

Dihydropteroyl hexaglutamate

CAS#49637-65-2

Theoretical Analysis

MedKoo Cat#: 597247

Name: Dihydropteroyl hexaglutamate

CAS#: 49637-65-2

Chemical Formula: C44H56N12O21

Exact Mass: 1088.3683

Molecular Weight: 1088.99

Elemental Analysis: C, 48.53; H, 5.18; N, 15.43; O, 30.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Dihydropteroyl hexaglutamate;

IUPAC/Chemical Name

(3S,8S,13S,18S,23S,28S)-1-(4-(((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)amino)phenyl)-1,6,11,16,21,26-hexaoxo-2,7,12,17,22,27-hexaazatriacontane-3,8,13,18,23,28,30-heptacarboxylic acid

InChi Key

VAFWKCXKYMXFRJ-QCOJBMJGSA-N

InChi Code

InChI=1S/C44H56N12O21/c45-44-55-35-34(37(65)56-44)48-21(18-47-35)17-46-20-3-1-19(2-4-20)36(64)54-27(43(76)77)9-15-32(61)52-25(41(72)73)7-13-30(59)50-23(39(68)69)5-11-28(57)49-22(38(66)67)6-12-29(58)51-24(40(70)71)8-14-31(60)53-26(42(74)75)10-16-33(62)63/h1-4,22-27,46H,5-18H2,(H,49,57)(H,50,59)(H,51,58)(H,52,61)(H,53,60)(H,54,64)(H,62,63)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H4,45,47,55,56,65)/t22-,23-,24-,25-,26-,27-/m0/s1

SMILES Code

O=C(O)CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(NC(N)=NC3=O)NC2)C=C1)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,088.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kozloff LM. A structural role for dihydropteroyl hexaglutamate in the tail baseplate of various bacteriophages. Adv Exp Med Biol. 1983;163:359-74. PubMed PMID: 6351553. 2: Kozloff LM. Folyl polyglutamate and folate-requiring enzymes as bacteriophage T4D baseplate structural components. Biosystems. 1980;12(3-4):239-47. PubMed PMID: 6994831. 3: Kozloff LM, Crosby LK, Baugh CM. Structural role of the polyglutamate portion of the folate found in T4D bacteriophage baseplate. J Virol. 1979 Nov;32(2):497-506. PubMed PMID: 501801; PubMed Central PMCID: PMC353581.