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MedKoo Cat#: 563122 | Name: N4Py

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N4Py is an excellent synthetic mimic of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.

Chemical Structure

N4Py
N4Py
CAS#167695-87-6

Theoretical Analysis

MedKoo Cat#: 563122

Name: N4Py

CAS#: 167695-87-6

Chemical Formula: C23H21N5

Exact Mass: 367.1797

Molecular Weight: 367.45

Elemental Analysis: C, 75.18; H, 5.76; N, 19.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
N4Py; N-4-Py; N 4 Py;
IUPAC/Chemical Name
1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine
InChi Key
PRICLFAUAJHZLI-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N5/c1-5-13-24-19(9-1)17-28(18-20-10-2-6-14-25-20)23(21-11-3-7-15-26-21)22-12-4-8-16-27-22/h1-16,23H,17-18H2
SMILES Code
C1(C(N(CC2=NC=CC=C2)CC3=CC=CC=N3)C4=CC=CC=N4)=NC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Geersing A, Ségaud N, van der Wijst MGP, Rots MG, Roelfes G. Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py. Inorg Chem. 2018 Jun 19. doi: 10.1021/acs.inorgchem.8b00714. [Epub ahead of print] PubMed PMID: 29916702. 2: Chen PY, Tseng TH. A Switch from Mechanistic Competition Mediated by a Coordination between Temperature and Concentration Effects in the Oxidation Reaction of [FeII(N4Py/TPA)](OTf)2. Chemistry. 2018 Jun 11. doi: 10.1002/chem.201801028. [Epub ahead of print] PubMed PMID: 29889323. 3: Chen J, Unjaroen D, Stepanovic S, van Dam A, Gruden M, Browne WR. Selective Photo-Induced Oxidation with O(2) of a Non-Heme Iron(III) Complex to a Bis(imine-pyridyl)iron(II) Complex. Inorg Chem. 2018 Apr 16;57(8):4510-4515. doi: 10.1021/acs.inorgchem.8b00187. Epub 2018 Mar 30. PubMed PMID: 29601196; PubMed Central PMCID: PMC5906753. 4: Draksharapu A, Rasheed W, Klein JEMN, Que L Jr. Facile and Reversible Formation of Iron(III)-Oxo-Cerium(IV) Adducts from Nonheme Oxoiron(IV) Complexes and Cerium(III). Angew Chem Int Ed Engl. 2017 Jul 24;56(31):9091-9095. doi: 10.1002/anie.201704322. Epub 2017 Jun 27. PubMed PMID: 28598024; PubMed Central PMCID: PMC5598155. 5: Andris E, Navrátil R, Jašík J, Terencio T, Srnec M, Costas M, Roithová J. Chasing the Evasive Fe═O Stretch and the Spin State of the Iron(IV)-Oxo Complexes by Photodissociation Spectroscopy. J Am Chem Soc. 2017 Feb 22;139(7):2757-2765. doi: 10.1021/jacs.6b12291. Epub 2017 Feb 9. PubMed PMID: 28125220. 6: Unjaroen D, Chen J, Otten E, Browne WR. Switching Pathways for Reversible Ligand Photodissociation in Ru(II) Polypyridyl Complexes with Steric Effects. Inorg Chem. 2017 Jan 17;56(2):900-907. doi: 10.1021/acs.inorgchem.6b02521. Epub 2017 Jan 3. PubMed PMID: 28045515. 7: Barbieri A, Del Giacco T, Di Stefano S, Lanzalunga O, Lapi A, Mazzonna M, Olivo G. Electron Transfer Mechanism in the Oxidation of Aryl 1-Methyl-1-phenylethyl Sulfides Promoted by Nonheme Iron(IV)-Oxo Complexes: The Rate of the Oxygen Rebound Process. J Org Chem. 2016 Dec 16;81(24):12382-12387. Epub 2016 Dec 2. PubMed PMID: 27978740. 8: Leto DF, Massie AA, Rice DB, Jackson TA. Spectroscopic and Computational Investigations of a Mononuclear Manganese(IV)-Oxo Complex Reveal Electronic Structure Contributions to Reactivity. J Am Chem Soc. 2016 Nov 30;138(47):15413-15424. Epub 2016 Nov 15. PubMed PMID: 27802057. 9: Sahu S, Zhang B, Pollock CJ, Dürr M, Davies CG, Confer AM, Ivanović-Burmazović I, Siegler MA, Jameson GN, Krebs C, Goldberg DP. Aromatic C-F Hydroxylation by Nonheme Iron(IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations. J Am Chem Soc. 2016 Oct 5;138(39):12791-12802. Epub 2016 Sep 22. PubMed PMID: 27656776; PubMed Central PMCID: PMC5628738. 10: Puri M, Company A, Sabenya G, Costas M, Que L Jr. Oxygen Atom Exchange between H2O and Non-Heme Oxoiron(IV) Complexes: Ligand Dependence and Mechanism. Inorg Chem. 2016 Jun 20;55(12):5818-27. doi: 10.1021/acs.inorgchem.6b00023. Epub 2016 Jun 8. PubMed PMID: 27275633. 11: Jung J, Kim S, Lee YM, Nam W, Fukuzumi S. Switchover of the Mechanism between Electron Transfer and Hydrogen-Atom Transfer for a Protonated Manganese(IV)-Oxo Complex by Changing Only the Reaction Temperature. Angew Chem Int Ed Engl. 2016 Jun 20;55(26):7450-4. doi: 10.1002/anie.201602460. Epub 2016 May 18. PubMed PMID: 27191357. 12: Lo WK, Castillo CE, Gueret R, Fortage J, Rebarz M, Sliwa M, Thomas F, McAdam CJ, Jameson GB, McMorran DA, Crowley JD, Collomb MN, Blackman AG. Synthesis, Characterization, and Photocatalytic H2-Evolving Activity of a Family of [Co(N4Py)(X)](n+) Complexes in Aqueous Solution. Inorg Chem. 2016 May 2;55(9):4564-81. doi: 10.1021/acs.inorgchem.6b00391. Epub 2016 Apr 11. PubMed PMID: 27064169. 13: Barbieri A, De Carlo Chimienti R, Del Giacco T, Di Stefano S, Lanzalunga O, Lapi A, Mazzonna M, Olivo G, Salamone M. Oxidation of Aryl Diphenylmethyl Sulfides Promoted by a Nonheme Iron(IV)-Oxo Complex: Evidence for an Electron Transfer-Oxygen Transfer Mechanism. J Org Chem. 2016 Mar 18;81(6):2513-20. doi: 10.1021/acs.joc.6b00099. Epub 2016 Feb 25. Erratum in: J Org Chem. 2016 May 6;81(9):3981. PubMed PMID: 26886491. 14: Mitra M, Nimir H, Demeshko S, Bhat SS, Malinkin SO, Haukka M, Lloret-Fillol J, Lisensky GC, Meyer F, Shteinman AA, Browne WR, Hrovat DA, Richmond MG, Costas M, Nordlander E. Nonheme Fe(IV) Oxo Complexes of Two New Pentadentate Ligands and Their Hydrogen-Atom and Oxygen-Atom Transfer Reactions. Inorg Chem. 2015 Aug 3;54(15):7152-64. doi: 10.1021/ic5029564. Epub 2015 Jul 22. PubMed PMID: 26198840. 15: Chen J, Cho KB, Lee YM, Kwon YH, Nam W. Mononuclear nonheme iron(IV)-oxo and manganese(IV)-oxo complexes in oxidation reactions: experimental results prove theoretical prediction. Chem Commun (Camb). 2015 Aug 25;51(66):13094-7. doi: 10.1039/c5cc04217h. PubMed PMID: 26186554. 16: Chen J, Yoon H, Lee YM, Seo MS, Sarangi R, Fukuzumi S, Nam W. Tuning the Reactivity of Mononuclear Nonheme Manganese(IV)-Oxo Complexes by Triflic Acid. Chem Sci. 2015 Jun 1;6(6):3624-3632. PubMed PMID: 26146538; PubMed Central PMCID: PMC4486364. 17: Lo WK, Huff GS, Preston D, McMorran DA, Giles GI, Gordon KC, Crowley JD. A Dinuclear Platinum(II) N4Py Complex: An Unexpected Coordination Mode For N4Py. Inorg Chem. 2015 Jul 20;54(14):6671-3. doi: 10.1021/acs.inorgchem.5b01032. Epub 2015 Jun 30. PubMed PMID: 26126121. 18: Park J, Lee YM, Ohkubo K, Nam W, Fukuzumi S. Efficient Epoxidation of Styrene Derivatives by a Nonheme Iron(IV)-Oxo Complex via Proton-Coupled Electron Transfer with Triflic Acid. Inorg Chem. 2015 Jun 15;54(12):5806-12. doi: 10.1021/acs.inorgchem.5b00504. Epub 2015 May 26. PubMed PMID: 26010774. 19: Barbieri A, De Gennaro M, Di Stefano S, Lanzalunga O, Lapi A, Mazzonna M, Olivo G, Ticconi B. Isotope effect profiles in the N-demethylation of N,N-dimethylanilines: a key to determine the pK(a) of nonheme Fe(III)-OH complexes. Chem Commun (Camb). 2015 Mar 25;51(24):5032-5. doi: 10.1039/c5cc00411j. PubMed PMID: 25706886. 20: Xie J, Zhou Q, Li C, Wang W, Hou Y, Zhang B, Wang X. An unexpected role of the monodentate ligand in photocatalytic hydrogen production of the pentadentate ligand-based cobalt complexes. Chem Commun (Camb). 2014 Jun 21;50(49):6520-2. doi: 10.1039/c4cc01471e. Epub 2014 May 13. PubMed PMID: 24820402.