IQ3 | CAS#312538-03-7 | JNK3 inhibitor

MedKoo Cat#: 563090 | Name: IQ3

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IQ3 is a small molecule that functions primarily as a selective inhibitor of IQGAP1–ERK1/2 interactions, disrupting a key scaffold protein complex involved in RAS-MAPK signaling. By blocking this interaction, IQ3 effectively reduces ERK-mediated proliferation and survival signals, particularly in cancer cells. It has shown bioactivity in preclinical models of breast cancer, melanoma, and other tumors, demonstrating its potential as a targeted anticancer agent.

Chemical Structure

IQ3

CAS#312538-03-7

Theoretical Analysis

MedKoo Cat#: 563090

Name: IQ3

CAS#: 312538-03-7

Chemical Formula: C20H11N3O3

Exact Mass: 341.0800

Molecular Weight: 341.33

Elemental Analysis: C, 70.38; H, 3.25; N, 12.31; O, 14.06

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450.00	2 Weeks
25mg	USD 750.00	2 Weeks

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Related CAS #

No Data

Synonym

IQ3; IQ-3; IQ 3;

IUPAC/Chemical Name

11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime

InChi Key

WBSWWONMTZEOGS-PTGBLXJZSA-N

InChi Code

InChI=1S/C20H11N3O3/c24-20(16-10-5-11-25-16)26-23-18-13-7-2-1-6-12(13)17-19(18)22-15-9-4-3-8-14(15)21-17/h1-11H/b23-18+

SMILES Code

O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	15.0	43.95

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 341.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

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