MedKoo Cat#: 130188 | Name: CRTH2 antagonist K604

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CRTH2 antagonist K604 is a CRTH2 antagonist (Ki=11 nM) with inhibitory effects. It has been hypothesized that CRTH2 plays an important role in the development/progression/outcome of allergic diseases, with K604 serving as a potential route for exploring the extent of CRTH2 involvement.

Chemical Structure

CRTH2 antagonist K604
CRTH2 antagonist K604
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130188

Name: CRTH2 antagonist K604

CAS#: N/A

Chemical Formula: C27H26N2O2

Exact Mass: 410.1994

Molecular Weight: 410.52

Elemental Analysis: C, 79.00; H, 6.38; N, 6.82; O, 7.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CRTH2 antagonist K604
IUPAC/Chemical Name
N-((2R,4S)-1-benzoyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylcyclopropanecarboxamide
InChi Key
VGFZCFWVSYIXEK-CLOONOSVSA-N
InChi Code
InChI=1S/C27H26N2O2/c1-19-18-25(29(27(31)21-16-17-21)22-12-6-3-7-13-22)23-14-8-9-15-24(23)28(19)26(30)20-10-4-2-5-11-20/h2-15,19,21,25H,16-18H2,1H3/t19-,25+/m1/s1
SMILES Code
O=C(C1CC1)N([C@H]2C[C@@H](C)N(C(C3=CC=CC=C3)=O)C4=C2C=CC=C4)C5=CC=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Mimura H, Ikemura T, Kotera O, Sawada M, Tashiro S, Fuse E, Ueno K, Manabe H, Ohshima E, Karasawa A, Miyaji H. Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2. J Pharmacol Exp Ther. 2005 Jul;314(1):244-51. doi: 10.1124/jpet.104.081539. Epub 2005 Mar 29. PMID: 15798001.