Synonym
Flutonidine; ST600; ST-600; ST 600;
IUPAC/Chemical Name
N-(5-Fluoro-2-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
InChi Key
UYIZEUBMWCOJFF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12FN3/c1-7-2-3-8(11)6-9(7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)
SMILES Code
CC1=CC=C(F)C=C1NC2=NCCN2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
193.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Thomas GP, Varma RK. Effect of flutonidine on ouabain-induced arrhythmias and lethality in guinea-pig. Pharmacol Res. 1993 May-Jun;27(4):365-71. PubMed PMID: 8103597.
2: Naidu MU, Yulu AV, Thapar GS, Krishnamurthy A. Diuretic effects of flutonidine, a newer clonidine analog. Indian J Exp Biol. 1987 Jan;25(1):29-32. PubMed PMID: 3610239.
3: Kast A, Muacevic G. Reversible pulmonary changes in rats dosed intravenously with imidazoles. J Toxicol Sci. 1986 Feb;11(1):67-77. PubMed PMID: 3712507.
4: Kobinger W. Rudolf Buchheim lecture. Drugs as tools in research on adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1986 Feb;332(2):113-23. Review. PubMed PMID: 3010138.
5: Nicrosini F, Pasotti C. [Long-term treatment with a new antihypertensive drug: flutonidin]. Minerva Med. 1983 May 19;74(21):1297-300. Italian. PubMed PMID: 6406947.
6: Veeranjaneyulu A, Verma SC. alpha-Adrenoceptor activity of flutonidine (ST 600) in rat anococcygeus muscle and rabbit jejunum. J Pharm Pharmacol. 1982 Apr;34(4):270-2. PubMed PMID: 6124607.
7: Salvadeo A, Segagni S, Villa G, Galli F, Piazza W, Bovio G. A comparative trial of timolol and flutonidin as antihypertensive agents. Int J Clin Pharmacol Ther Toxicol. 1982 Feb;20(2):78-84. PubMed PMID: 7037661.
8: Mazzola C, Guffanti E, Ferrario N. Cardiovascular effects of flutonidin after acute oral administration. Farmaco Prat. 1981 May;36(5):262-70. PubMed PMID: 7238849.
9: Marmo E, Di Mezza F, Nistico G, Somma A, Ariello B, Imperatore A. Central cardiovascular effects of flutonidine in adult fowls. Agressologie. 1981;22(6):269-72. PubMed PMID: 7325301.
10: Summers RJ, Jarrott B, Louis WJ. Selectivity of a series of clonidine-like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain. Neurosci Lett. 1980 Dec;20(3):347-50. PubMed PMID: 6255379.
11: Imperatore A, Vairo G, Lampa E, Sasso M, Ottavo R, Scognamiglio R. [Platelet aggregation and antihypertensive alpha-adrenergic agonists]. Arch Sci Med (Torino). 1980 Apr-Jun;137(2):241-6. Italian. PubMed PMID: 6111990.
