MedKoo Cat#: 563018 | Name: GSK329
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK329 is a highly potent and moderately selective TNNI3K inhibitor.

Chemical Structure

GSK329
GSK329
CAS#1268490-12-5

Theoretical Analysis

MedKoo Cat#: 563018

Name: GSK329

CAS#: 1268490-12-5

Chemical Formula: C19H14Cl2F3N5O2

Exact Mass: 471.0477

Molecular Weight: 472.24

Elemental Analysis: C, 48.32; H, 2.99; Cl, 15.01; F, 12.07; N, 14.83; O, 6.78

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK329; GSK-329; GSK 329;
IUPAC/Chemical Name
1-(3,5-dichloro-4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChi Key
QOQADIYOLOHRAW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14Cl2F3N5O2/c1-25-15-8-16(27-9-26-15)31-17-13(20)6-12(7-14(17)21)29-18(30)28-11-4-2-3-10(5-11)19(22,23)24/h2-9H,1H3,(H,25,26,27)(H2,28,29,30)
SMILES Code
CNC1=CC(=NC=N1)OC2=C(C=C(C=C2Cl)NC(=O)NC3=CC=CC(=C3)C(F)(F)F)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Patterson JR, Graves AP, Stoy P, Cheung M, Desai TA, Fries H, Gatto GJ Jr, Holt DA, Shewchuk L, Totoritis R, Wang L, Kallander LS. Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf. J Med Chem. 2021 Nov 11;64(21):15651-15670. doi: 10.1021/acs.jmedchem.1c00700. Epub 2021 Oct 26. PMID: 34699203.