MedKoo Cat#: 561684 | Name: Honokiol DCA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Honokiol DCA is an inhibitor of the phosphorylation of DRP1. It stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo.

Chemical Structure

Honokiol DCA
Honokiol DCA
CAS#1620160-42-0

Theoretical Analysis

MedKoo Cat#: 561684

Name: Honokiol DCA

CAS#: 1620160-42-0

Chemical Formula: C22H18Cl4O4

Exact Mass: 485.9959

Molecular Weight: 488.18

Elemental Analysis: C, 54.13; H, 3.72; Cl, 29.05; O, 13.11

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Honokiol DCA; Honokiol Bis-Dichloroacetate;
IUPAC/Chemical Name
2'-[(2,2-Dichloroacetyl)oxy]-3,5'-di-2-propen-1-yl[1,1'-biphenyl]-4-yl 2,2-dichloroacetate
InChi Key
KSJLHVAHFGNFFU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18Cl4O4/c1-3-5-13-7-9-18(30-22(28)20(25)26)16(11-13)14-8-10-17(15(12-14)6-4-2)29-21(27)19(23)24/h3-4,7-12,19-20H,1-2,5-6H2
SMILES Code
O=C(OC1=CC=C(C2=CC(CC=C)=CC=C2OC(C(Cl)Cl)=O)C=C1CC=C)C(Cl)Cl
Appearance
Liquid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 488.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bonner MY, Karlsson I, Rodolfo M, Arnold RS, Vergani E, Arbiser JL. Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo. Oncotarget. 2016 Mar 15;7(11):12857-68. doi: 10.18632/oncotarget.7289. PubMed PMID: 26871475; PubMed Central PMCID: PMC4914326.