OPC-163493 | CAS#1644467-84-4 | mitochondrial uncoupler

MedKoo Cat#: 462066 | Name: OPC-163493

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OPC-163493 is a protonophore mitochondrial uncoupler.

Chemical Structure

OPC-163493

CAS#1644467-84-4

Theoretical Analysis

MedKoo Cat#: 462066

Name: OPC-163493

CAS#: 1644467-84-4

Chemical Formula: C14H8F3N5S

Exact Mass: 335.0453

Molecular Weight: 335.31

Elemental Analysis: C, 50.15; H, 2.40; F, 17.00; N, 20.89; S, 9.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1644467-84-4 1644657-18-0

Synonym

OPC-163493; OPC163493; OPC 163493

IUPAC/Chemical Name

4-(5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)-1H-1,2,3-triazole-5-carbonitrile

InChi Key

HRPOFNGLAQYGDC-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H8F3N5S/c1-7-11(12-10(6-18)20-22-21-12)19-13(23-7)8-2-4-9(5-3-8)14(15,16)17/h2-5H,1H3,(H,20,21,22)

SMILES Code

FC(F)(F)C1=CC=C(C2=NC(C3=C(C#N)NN=N3)=C(C)S2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler Naohide Kanemoto, Takashi Okamoto, Koji Tanabe, Takahiro Shimada, Hitomi Minoshima, Yuya Hidoh, Masashi Aoyama, Takashi Ban, Yusuke Kobayashi, Hikaru Ando, Yuki Inoue, Motohiro Itotani, Seiji Sato Nat Commun. 2019; 10: 2172. Published online 2019 May 15. doi: 10.1038/s41467-019-09911-6 PMCID: PMC6520346 2: Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn Nat Commun. 2020; 11: 2397. Published online 2020 May 14. doi: 10.1038/s41467-020-16298-2 PMCID: PMC7224297