Synonym
TAS-4; TAS 4; TAS4;
IUPAC/Chemical Name
N-(2,4-Dichlorophenyl)pyridine-2-carboxamide
InChi Key
ZNMWFDKCPWCBBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H8Cl2N2O/c13-8-4-5-10(9(14)7-8)16-12(17)11-3-1-2-6-15-11/h1-7H,(H,16,17)
SMILES Code
O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C=C2Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
267.10
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dube A, Chaudhary S, Mengawade T, Upasani CD. Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders. J Neurol Sci. 2014 Jul 10. pii: S0022-510X(14)00452-3. doi: 10.1016/j.jns.2014.07.008. [Epub ahead of print] PubMed PMID: 25073574.
2: Urata C, Masheder B, Cheng DF, Hozumi A. Unusual dynamic dewetting behavior of smooth perfluorinated hybrid films: potential advantages over conventional textured and liquid-infused perfluorinated surfaces. Langmuir. 2013 Oct 8;29(40):12472-82. doi: 10.1021/la402714s. Epub 2013 Sep 24. PubMed PMID: 24020591.
3: Ozatik O, Aydin Y, Hassa H, Ulusoy D, Ogut S, Sahin F. Relationship between oxidative stress and clinical pregnancy in assisted reproductive technology treatment cycles. J Assist Reprod Genet. 2013 Jun;30(6):765-72. doi: 10.1007/s10815-013-0005-2. Epub 2013 May 11. Erratum in: J Assist Reprod Genet. 2014 Nov;31(11):1569. PubMed PMID: 23666546; PubMed Central PMCID: PMC3696458.
4: Chahal J, Bush-Joseph CA, Chow A, Zelazny A, Mather RC 3rd, Lin EC, Gupta D, Verma NN. Clinical and magnetic resonance imaging outcomes after surgical repair of complete proximal hamstring ruptures: does the tendon heal? Am J Sports Med. 2012 Oct;40(10):2325-30. Epub 2012 Aug 6. PubMed PMID: 22869623.
5: Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54. PubMed PMID: 16595895.
6: Xing D, Kjølbye AL, Petersen JS, Martins JB. Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H511-6. PubMed PMID: 15650154.
7: Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr. 2002 Oct;88(4):389-98. PubMed PMID: 12323088.
8: Boldt J, Walz G, Triem J, Suttner S, Kumle B. Point-of-care (POC) measurement of coagulation after cardiac surgery. Intensive Care Med. 1998 Nov;24(11):1187-93. PubMed PMID: 9876982.
9: Sawyer JR, Swanson CM, Roloson GJ, Longee DC, Chadduck WM. Cytogenetic findings in a case of pediatric glioblastoma. Cancer Genet Cytogenet. 1992 Nov;64(1):75-9. PubMed PMID: 1333880.