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MedKoo Cat#: 563007 | Name: Ladanein

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ladanein is an inhibitor of HCV entering into human hepatocytes irrespective of genotype.

Chemical Structure

Ladanein
Ladanein
CAS#10176-71-3

Theoretical Analysis

MedKoo Cat#: 563007

Name: Ladanein

CAS#: 10176-71-3

Chemical Formula: C17H14O6

Exact Mass: 314.0790

Molecular Weight: 314.29

Elemental Analysis: C, 64.97; H, 4.49; O, 30.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ladanein;
IUPAC/Chemical Name
5,6-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
InChi Key
UUQJTIHOVGMQIH-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)12-7-11(18)15-13(23-12)8-14(22-2)16(19)17(15)20/h3-8,19-20H,1-2H3
SMILES Code
O=C1C=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=C(O)C(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ismail NA, Jusoh SA. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511. doi: 10.1007/s12539-016-0157-8. Epub 2016 Mar 11. PubMed PMID: 26969331. 2: Peter SR, Peru KM, Fahlman B, McMartin DW, Headley JV. The application of HPLC ESI MS in the investigation of the flavonoids and flavonoid glycosides of a Caribbean Lamiaceae plant with potential for bioaccumulation. J Environ Sci Health B. 2015;50(11):819-26. doi: 10.1080/03601234.2015.1058103. PubMed PMID: 26357892. 3: Ribeiro FF, Junior FJ, da Silva MS, Scotti MT, Scotti L. Computational and Investigative Study of Flavonoids Active Against Typanosoma cruzi and Leishmania spp. Nat Prod Commun. 2015 Jun;10(6):917-20. PubMed PMID: 26197515. 4: Mathew S, Faheem M, Archunan G, Ilyas M, Begum N, Jahangir S, Qadri I, Qahtani MA, Mathew S. In silico studies of medicinal compounds against hepatitis C capsid protein from north India. Bioinform Biol Insights. 2014 Jun 23;8:159-68. doi: 10.4137/BBI.S15211. eCollection 2014. PubMed PMID: 25002815; PubMed Central PMCID: PMC4076477. 5: Farjam MH, Rustaiyan A, Ezzatzadeh E, Jassbi AR. Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities. Iran J Pharm Res. 2013 Spring;12(2):395-400. PubMed PMID: 24250614; PubMed Central PMCID: PMC3813239. 6: Calland N, Dubuisson J, Rouillé Y, Séron K. Hepatitis C virus and natural compounds: a new antiviral approach? Viruses. 2012 Oct 17;4(10):2197-217. doi: 10.3390/v4102197. Review. PubMed PMID: 23202460; PubMed Central PMCID: PMC3497048. 7: Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 2012 Jul;143(1):213-22.e5. doi: 10.1053/j.gastro.2012.03.036. Epub 2012 Mar 27. PubMed PMID: 22465429. 8: Gohari AR, Saeidnia S, Malmir M, Hadjiakhoondi A, Ajani Y. Flavones and rosmarinic acid from Salvia limbata. Nat Prod Res. 2010 Dec;24(20):1902-6. doi: 10.1080/14786411003766912. PubMed PMID: 21108116. 9: Bai N, He K, Roller M, Lai CS, Shao X, Pan MH, Ho CT. Flavonoids and phenolic compounds from Rosmarinus officinalis. J Agric Food Chem. 2010 May 12;58(9):5363-7. doi: 10.1021/jf100332w. PubMed PMID: 20397728. 10: Alkhatib R, Joha S, Cheok M, Roumy V, Idziorek T, Preudhomme C, Quesnel B, Sahpaz S, Bailleul F, Hennebelle T. Activity of ladanein on leukemia cell lines and its occurrence in Marrubium vulgare. Planta Med. 2010 Jan;76(1):86-7. doi: 10.1055/s-0029-1185972. Epub 2009 Jul 30. PubMed PMID: 19644796. 11: Argyropoulou C, Karioti A, Skaltsa H. Labdane diterpenes from Marrubium thessalum. Phytochemistry. 2009 Mar;70(5):635-40. doi: 10.1016/j.phytochem.2009.03.011. Epub 2009 Apr 8. PubMed PMID: 19361824. 12: Wu X, Liu J, Yu ZB, Ye YH, Zhou YW. [Studies on flavones in of Lavandula augustifolia]. Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):821-3. Chinese. PubMed PMID: 17639984. 13: Seo JM, Kang HM, Son KH, Kim JH, Lee CW, Kim HM, Chang SI, Kwon BM. Antitumor activity of flavones isolated from Artemisia argyi. Planta Med. 2003 Mar;69(3):218-22. PubMed PMID: 12677524. 14: Tezuka Y, Stampoulis P, Banskota AH, Awale S, Tran KQ, Saiki I, Kadota S. Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1711-9. PubMed PMID: 11086900. 15: Barberán FA, Hernández L, Ferreres F, Tomás F. Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. Planta Med. 1985 Oct;51(5):452-4. PubMed PMID: 17342612.

View History

NSC-33377

NSC-33377