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MedKoo Cat#: 592439 | Name: Promothiocin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Promothiocin A is an antibiotic.

Chemical Structure

Promothiocin A
Promothiocin A
CAS#156737-05-2

Theoretical Analysis

MedKoo Cat#: 592439

Name: Promothiocin A

CAS#: 156737-05-2

Chemical Formula: C36H46N11O8S2

Exact Mass: 824.2972

Molecular Weight: 824.95

Elemental Analysis: C, 52.41; H, 5.62; N, 18.68; O, 15.52; S, 7.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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No Data
Synonym
Promothiocin A; Antibiotic SF-2741A; Antibiotic SF 2741A; Antibiotic SF2741A
IUPAC/Chemical Name
Alaninamide, L-valyl-2-(aminomethyl)-5-methyl-4-oxazolecarbonyl-2-((1S)-1-aminoethyl)-4-thiazolecarbonyl-6-(2-((1S)-1-aminoethyl)-5-methyl-4-oxazolyl)-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydro-, (4->1)-lactam
InChi Key
GYMOXWLLOBRNGV-IYOCKNTQSA-N
InChi Code
InChI=1S/C36H46N11O8S2/c1-13(2)24-32(52)38-10-23-45-26(18(7)54-23)33(53)41-16(5)35-43-21(11-56-35)30(50)40-15(4)34-47-25(17(6)55-34)27-19(36-44-22(12-57-36)31(51)46-24)8-9-20(42-27)29(49)39-14(3)28(37)48/h8-9,12-13,15-18,21,23-26,34-35H,3,10-11H2,1-2,4-7H3,(H2,37,48)(H,38,52)(H,39,49)(H,40,50)(H,41,53)(H,46,51)/t15-,16-,17?,18?,21?,23?,24-,25?,26?,34?,35?/m0/s1
SMILES Code
Cc1c-2nc(o1)[C@@H](NC(=O)c3csc(n3)[C@@H](NC(=O)c4c(oc(n4)CNC(=O)[C@@H](NC(=O)c5csc(n5)-c6c2nc(cc6)C(=O)NC(=C)C(=O)N)C(C)C)C)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 824.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Habazettl J, Allan M, Jensen PR, Sass HJ, Thompson CJ, Grzesiek S. Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5498-507. doi: 10.1073/pnas.1412070111. Epub 2014 Dec 8. PubMed PMID: 25489067; PubMed Central PMCID: PMC4280590. 2: Takagi M, Motohashi K, Nagai A, Hashimoto J, Shin-Ya K. JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19. J Antibiot (Tokyo). 2010 Jul;63(7):405-8. doi: 10.1038/ja.2010.66. Epub 2010 Jun 16. PubMed PMID: 20551986. 3: Yun BS, Hidaka T, Furihata K, Seto H. Promothiocins A and B novel thiopeptides with a tipA promoter inducing activity produced by Streptomyces sp. SF2741. J Antibiot (Tokyo). 1994 Apr;47(4):510-4. PubMed PMID: 8195055.

View History

CP-199330

CP-199330