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MedKoo Cat#: 562777 | Name: TRAM39
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRAM-39 is a selective inhibitor of the calcium-activated potassium channel KCa3.1 (IK1, SK4), which regulates membrane potential and ion flux in immune and vascular cells. By blocking KCa3.1 activity, TRAM-39 suppresses T-cell activation, proliferation, and cytokine release, making it a promising immunomodulatory agent. Its potential therapeutic applications include the treatment of autoimmune diseases, inflammatory disorders, and vascular pathologies.

Chemical Structure

TRAM39
TRAM39
CAS#197525-99-8

Theoretical Analysis

MedKoo Cat#: 562777

Name: TRAM39

CAS#: 197525-99-8

Chemical Formula: C20H14ClN

Exact Mass: 303.0815

Molecular Weight: 303.78

Elemental Analysis: C, 79.07; H, 4.65; Cl, 11.67; N, 4.61

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
TRAM39; TRAM-39; TRAM 39;
IUPAC/Chemical Name
2-Chloro-α,α-diphenylbenzeneacetonitrile
InChi Key
JHNRTPKGSCVKKC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14ClN/c21-19-14-8-7-13-18(19)20(15-22,16-9-3-1-4-10-16)17-11-5-2-6-12-17/h1-14H
SMILES Code
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: So EC, Gao ZH, Ko SY, Wu SN. Characterization of Effectiveness in Concerted Ih Inhibition and IK(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid. Int J Mol Sci. 2020 Jan 5;21(1):357. doi: 10.3390/ijms21010357. PMID: 31948124; PMCID: PMC6981816. 2: Huang MH, Liu PY, Wu SN. Characterization of Perturbing Actions by Verteporfin, a Benzoporphyrin Photosensitizer, on Membrane Ionic Currents. Front Chem. 2019 Aug 22;7:566. doi: 10.3389/fchem.2019.00566. PMID: 31508407; PMCID: PMC6714490. 3: Chen TS, Lai MC, Hung TY, Lin KM, Huang CW, Wu SN. Pioglitazone, a PPAR-γ Activator, Stimulates BKCa but Suppresses IK M in Hippocampal Neurons. Front Pharmacol. 2018 Aug 29;9:977. doi: 10.3389/fphar.2018.00977. PMID: 30210346; PMCID: PMC6123368. 4: So EC, Wang Y, Yang LQ, So KH, Lo YC, Wu SN. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. Biochem Pharmacol. 2018 May;151:79-88. doi: 10.1016/j.bcp.2018.02.027. Epub 2018 Feb 23. PMID: 29477572. 5: Burnham MP, Johnson IT, Weston AH. Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br J Pharmacol. 2006 Jun;148(4):434-41. doi: 10.1038/sj.bjp.0706748. Epub 2006 May 8. PMID: 16682967; PMCID: PMC1751791. 6: Davies PJ, Thomas EA, Bornstein JC. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Auton Neurosci. 2006 Jan 30;124(1-2):26-30. doi: 10.1016/j.autneu.2005.10.006. Epub 2005 Dec 1. PMID: 16325477. 7: Weston AH, Absi M, Ward DT, Ohanian J, Dodd RH, Dauban P, Petrel C, Ruat M, Edwards G. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res. 2005 Aug 19;97(4):391-8. doi: 10.1161/01.RES.0000178787.59594.a0. Epub 2005 Jul 21. PMID: 16037572. 8: Weston AH, Félétou M, Vanhoutte PM, Falck JR, Campbell WB, Edwards G. Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol. 2005 Jul;145(6):775-84. doi: 10.1038/sj.bjp.0706256. PMID: 15895105; PMCID: PMC1576199. 9: Serrano-Mollar A, Closa D, Prats N, Blesa S, Martinez-Losa M, Cortijo J, Estrela JM, Morcillo EJ, Bulbena O. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br J Pharmacol. 2003 Mar;138(6):1037-48. doi: 10.1038/sj.bjp.0705138. PMID: 12684259; PMCID: PMC1573750. 10: Hinton JM, Langton PD. Inhibition of EDHF by two new combinations of K+-channel inhibitors in rat isolated mesenteric arteries. Br J Pharmacol. 2003 Mar;138(6):1031-5. doi: 10.1038/sj.bjp.0705171. PMID: 12684258; PMCID: PMC1573761. 11: Eichler I, Wibawa J, Grgic I, Knorr A, Brakemeier S, Pries AR, Hoyer J, Köhler R. Selective blockade of endothelial Ca2+-activated small- and intermediate-conductance K+-channels suppresses EDHF-mediated vasodilation. Br J Pharmacol. 2003 Feb;138(4):594-601. doi: 10.1038/sj.bjp.0705075. PMID: 12598413; PMCID: PMC1573692. 12: Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1;277(5):3793-800. doi: 10.1074/jbc.M107507200. Epub 2001 Nov 27. PMID: 11724775.