Synonym
S 2423; S-2423; S2423;
IUPAC/Chemical Name
(S)-4-((2S,3S)-2-acetamido-3-methylpentanamido)-5-((2-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)(4-nitrophenyl)amino)-2-oxoethyl)amino)-5-oxopentanoic acid
InChi Key
QRPSAVCTSLPNKZ-AEEVCGNZSA-N
InChi Code
InChI=1S/C27H41N9O9/c1-4-15(2)23(33-16(3)37)26(43)34-19(11-12-22(39)40)25(42)32-14-21(38)35(17-7-9-18(10-8-17)36(44)45)20(24(28)41)6-5-13-31-27(29)30/h7-10,15,19-20,23H,4-6,11-14H2,1-3H3,(H2,28,41)(H,32,42)(H,33,37)(H,34,43)(H,39,40)(H4,29,30,31)/t15-,19-,20-,23-/m0/s1
SMILES Code
N=C(N)NCCC[C@@H](C(N)=O)N(C(CNC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC(C)=O)=O)=O)=O)C1=CC=C([N+]([O-])=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
635.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Rokosz A, Górska P, Michałkiewicz J, Łuczak M. [Biological activity of lipopolysaccharides from clinical Bacteroides fragilis strains isolated in Poland determined in reaction with limulus amoebocyte lysate]. Med Dosw Mikrobiol. 2003;55(4):365-70. Polish. PubMed PMID: 15103996.
2: Rokosz A, Fiejka M, Górska P, Aleksandrowicz J, Meisel-Mikołajczyk F, Łuczak M. [Use of reactions with Limulus amoebocyte lysate (LAL) to determine biological activity of lipopolysaccharides from reference and clinical strains of the Bacteroides fragilis group]. Med Dosw Mikrobiol. 2002;54(4):365-9. Polish. PubMed PMID: 12650059.
3: Aleksandrowicz J, Fiejka M, Marciniak-Rusek A. [Level of bacterial endotoxins in Haemophilus influenzae type b vaccines conjugated with toxoids (td, Di)]. Med Dosw Mikrobiol. 1998;50(3-4):223-8. Polish. PubMed PMID: 10222737.
4: Kumar RS. Studies on proteases and alpha-macroglobulin activity in amphibian blood plasma. Indian J Exp Biol. 1997 Nov;35(11):1198-202. PubMed PMID: 9567750.
5: Rokosz A, Marciniak-Rusek A, Aleksandrowicz J, Meisel-Mikołajczyk F. [Use of the LAL test for quantitative determination of Bacteroids fragilis endotoxin]. Med Dosw Mikrobiol. 1997;49(3-4):161-8. Polish. PubMed PMID: 9554148.
6: Sturk A, Janssen ME, Muylaert FR, Joop K, Thomas LL, ten Cate JW. Endotoxin testing in blood. Prog Clin Biol Res. 1987;231:371-85. PubMed PMID: 3588631.
7: Olofsson P, Olofsson C, Nylander G, Olsson P. Endotoxin inactivation in plasma from patients with gram-negative infection--an in vitro study. Prog Clin Biol Res. 1987;231:323-30. PubMed PMID: 3588628.
8: Friberger P, Sörskog L, Nilsson K, Knös M. The use of a quantitative assay in endotoxin testing. Prog Clin Biol Res. 1987;231:149-69. PubMed PMID: 3588614.
9: van Noordwijk J, Hillen FC, Hagelen F. The relative activity of endotoxins of different origins in the LAL gelation method and in the LAL chromogenic substrate method. Prog Clin Biol Res. 1987;231:103-13. PubMed PMID: 3295884.
10: Olofsson P. Application of a quantitative spectrophotometric endotoxin assay on lymph and plasma from the rat. Eur Surg Res. 1986;18(2):112-21. PubMed PMID: 3519230.
11: Piotrowicz BI, Edlin SE, McCartney AC. A sensitive chromogenic Limulus amoebocyte lysate micro-assay for detection of endotoxin in human plasma and in water. Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Aug;260(1):108-12. PubMed PMID: 4060918.
12: Piotrowicz BI, Watt I, Edlin S, McCartney AC. A micromethod for endotoxin assay in human plasma using Limulus amoebocyte lysate and a chromogenic substrate. Eur J Clin Microbiol. 1985 Feb;4(1):52-4. PubMed PMID: 3987679.
13: Torano AE, Nakamura S, Levin J. Properties of the clotting enzyme responsible for endotoxin-mediated Limulus coagulation. Thromb Res. 1984 Jun 1;34(5):407-17. PubMed PMID: 6377572.
14: Aune S, Aasen AO, Kierulf P, Strømme JH. Quantitative determination of endotoxin in plasma by means of a new chromogenic peptide substrate. A methodological study. Acta Chir Scand Suppl. 1982;509:55-8. PubMed PMID: 6962620.