W452 | PfATP4 inhibitor

MedKoo Cat#: 128793 | Name: W452

Description:

WARNING: This product is for research use only, not for human or veterinary use.

W452 is a PfATP4 inhibitor.

Chemical Structure

W452

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128793

Name: W452

CAS#: N/A

Chemical Formula: C23H24N4O5

Exact Mass: 436.1747

Molecular Weight: 436.47

Elemental Analysis: C, 63.29; H, 5.54; N, 12.84; O, 18.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

W452; W 452; W-452

IUPAC/Chemical Name

2-(6-(5-ethyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)-N-(3,4,5-trimethoxyphenyl)acetamide

InChi Key

PGJBNHVLLPHGRB-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H24N4O5/c1-5-21-25-26-23(32-21)15-7-6-14-8-9-27(17(14)10-15)13-20(28)24-16-11-18(29-2)22(31-4)19(12-16)30-3/h6-12H,5,13H2,1-4H3,(H,24,28)

SMILES Code

O=C(CN1C(C=C(C2=NN=C(CC)O2)C=C3)=C3C=C1)NC4=CC(OC)=C(OC)C(OC)=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 436.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kim YI, Pascua PN, Kwon HI, Lim GJ, Kim EH, Yoon SW, Park SJ, Kim SM, Choi EJ, Si YJ, Lee OJ, Shim WS, Kim SW, Mo IP, Bae Y, Lim YT, Sung MH, Kim CJ, Webby RJ, Webster RG, Choi YK. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014 Oct;3(10):e75. doi: 10.1038/emi.2014.75. Epub 2014 Oct 22. PMID: 26038499; PMCID: PMC4217095. 2: Park SJ, Kim EH, Kwon HI, Song MS, Kim SM, Kim YI, Si YJ, Lee IW, Nguyen HD, Shin OS, Kim CJ, Choi YK. Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian models. Virulence. 2018 Jan 1;9(1):133-148. doi: 10.1080/21505594.2017.1366408. Epub 2017 Sep 21. PMID: 28873012; PMCID: PMC5955454. 3: Park SJ, Kumar M, Kwon HI, Seong RK, Han K, Song JM, Kim CJ, Choi YK, Shin OS. Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice. Sci Rep. 2015 Nov 18;5:16512. doi: 10.1038/srep16512. Erratum in: Sci Rep. 2016 Jan 29;6:20269. doi: 10.1038/srep20269. PMID: 26576844; PMCID: PMC4649622. 4: Betancourt SL, Palacio D, Jimenez CA, Martinez S, Marom EM. Thoracic manifestations of inflammatory bowel disease. AJR Am J Roentgenol. 2011 Sep;197(3):W452-6. doi: 10.2214/AJR.10.5353. PMID: 21862772. 5: Vicedomini R, Blachon C, Oteri F, Carbone A. MyCLADE: a multi-source domain annotation server for sequence functional exploration. Nucleic Acids Res. 2021 Jul 2;49(W1):W452-W458. doi: 10.1093/nar/gkab395. PMID: 34023906; PMCID: PMC8262732. 6: Kim SM, Kim YI, Park SJ, Kim EH, Kwon HI, Si YJ, Lee IW, Song MS, Choi YK. Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy. J Virol. 2017 Feb 28;91(6):e01693-16. doi: 10.1128/JVI.01693-16. PMID: 28077631; PMCID: PMC5331804. 7: Sim NL, Kumar P, Hu J, Henikoff S, Schneider G, Ng PC. SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W452-7. doi: 10.1093/nar/gks539. Epub 2012 Jun 11. PMID: 22689647; PMCID: PMC3394338. 8: Shridhar S, Chattopadhyay D, Yadav G. PLecDom: a program for identification and analysis of plant lectin domains. Nucleic Acids Res. 2009 Jul;37(Web Server issue):W452-8. doi: 10.1093/nar/gkp409. Epub 2009 May 27. PMID: 19474338; PMCID: PMC2703983. 9: Reimand J, Tooming L, Peterson H, Adler P, Vilo J. GraphWeb: mining heterogeneous biological networks for gene modules with functional significance. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W452-9. doi: 10.1093/nar/gkn230. Epub 2008 May 6. PMID: 18460544; PMCID: PMC2447774. 10: Morimoto M, Numata K, Kondo M, Nozaki A, Hamaguchi S, Takebayashi S, Tanaka K. C-arm cone beam CT for hepatic tumor ablation under real-time 3D imaging. AJR Am J Roentgenol. 2010 May;194(5):W452-4. doi: 10.2214/AJR.09.3514. PMID: 20410393.