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MedKoo Cat#: 591398 | Name: Estradiol dipropionate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Estradiol dipropionate is a semisynthetic, steroidal estrogen.

Chemical Structure

Estradiol dipropionate
Estradiol dipropionate
CAS#113-38-2 (dipropionate)

Theoretical Analysis

MedKoo Cat#: 591398

Name: Estradiol dipropionate

CAS#: 113-38-2 (dipropionate)

Chemical Formula: C24H32O4

Exact Mass: 384.2301

Molecular Weight: 384.52

Elemental Analysis: C, 74.97; H, 8.39; O, 16.64

Price and Availability

Size Price Availability Quantity
250mg USD 425.00 2 weeks
500mg USD 750.00 2 weeks
1g USD 1,250.00 2 weeks
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Related CAS #
50-28-2 50-50-0 (benzoate) 313-06-4 (cypionate) 113-38-2 (dipropionate) 172377-52-5 (sulfamate) 979-32-8 (valerate) 57-63-6 (ethinyl) 3571-53-7 (undecylate)
Synonym
Estradiol dipropionate; Estroici; Estronex; Follicyclin P
IUPAC/Chemical Name
(17beta)-Estra-1,3,5(10)-triene-3,17-diol, dipropanoate
InChi Key
JQIYNMYZKRGDFK-RUFWAXPRSA-N
InChi Code
InChI=1S/C24H32O4/c1-4-22(25)27-16-7-9-17-15(14-16)6-8-19-18(17)12-13-24(3)20(19)10-11-21(24)28-23(26)5-2/h7,9,14,18-21H,4-6,8,10-13H2,1-3H3/t18-,19-,20+,21+,24+/m1/s1
SMILES Code
C[C@@]12[C@@H](OC(CC)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OC(CC)=O)=C4)[C@@]3([H])CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 384.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nestorović N, Trifunović S, Manojlović-Stojanoski M, Jarić I, Ristić N, Filipović B, Šošić-Jurjević B, Milošević V. Soy Phytoestrogens Do Not Fully Reverse Changes in Rat Pituitary Castration Cells: Unbiased Stereological Study. Anat Rec (Hoboken). 2018 Mar 23. doi: 10.1002/ar.23809. [Epub ahead of print] PubMed PMID: 29569839. 2: Ristic N, Ajdzanovic V, Manojlovic-Stojanoski M, Maliković J, Uscebrka G, Markovic Z, Milosevic V. Effects of Estradiol on Histological Parameters and Secretory Ability of Pituitary Mammotrophs in Ovariectomized Female Rats. Cell J. 2017 Oct;19(3):461-468. doi: 10.22074/cellj.2017.4334. Epub 2017 Aug 19. PubMed PMID: 28836408; PubMed Central PMCID: PMC5570411. 3: Noguchi M, Ikedo T, Kawaguchi H, Tanimoto A. Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F2α. J Reprod Dev. 2016 Aug 25;62(4):373-8. doi: 10.1262/jrd.2015-169. Epub 2016 May 6. PubMed PMID: 27151362; PubMed Central PMCID: PMC5004793. 4: Šošić-Jurjević B, Filipović B, Renko K, Miler M, Trifunović S, Ajdžanovič V, Kӧhrle J, Milošević V. Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats. Exp Gerontol. 2015 Dec;72:85-98. doi: 10.1016/j.exger.2015.09.010. Epub 2015 Sep 15. PubMed PMID: 26384168. 5: Trifunović S, Manojlović-Stojanoski M, Ristić N, Nestorović N, Medigović I, Živanović J, Milošević V. Changes of growth hormone-releasing hormone and somatostatin neurons in the rat hypothalamus induced by genistein: a stereological study. Nutr Neurosci. 2016 Dec;19(10):467-474. Epub 2016 Mar 2. PubMed PMID: 25087680. 6: Trifunović S, Manojlović-Stojanoski M, Ajdžanović V, Nestorović N, Ristić N, Sošić-Jurjević B, Milošević V. Soy extract-dependent changes in morphofunctional parameters of the pituitary corticotropes in adult rats. Acta Histochem. 2014 Jun;116(5):717-22. doi: 10.1016/j.acthis.2013.12.010. Epub 2014 Jan 30. PubMed PMID: 24485333. 7: Filipović B, Sošić-Jurjević B, Ajdžanović V, Pantelić J, Nestorović N, Milošević V, Sekulić M. The effects of sex steroids on thyroid C cells and trabecular bone structure in the rat model of male osteoporosis. J Anat. 2013 Mar;222(3):313-20. doi: 10.1111/joa.12013. Epub 2012 Nov 21. PubMed PMID: 23171170; PubMed Central PMCID: PMC3582251. 8: Noguchi M, Kashiwai S, Itoh S, Okumura H, Kure K, Suzuki C, Yoshioka K. Reproductive hormone profiles in sows on estrus synchronization using estradiol dipropionate and prostaglandin F(2α)-analogue and the reproductive performance in female pigs on commercial farms. J Vet Med Sci. 2013;75(3):343-8. Epub 2012 Nov 5. PubMed PMID: 23131781. 9: Khomiak IV. [Ultrastructural peculiarities of mononuclear macrophages of the demarcation zone in an acute necrotic pancreatitis and elaborating of methods for the disease course prognosis and treatment]. Klin Khir. 2012 May;(5):27-31. Ukrainian. PubMed PMID: 22888547. 10: Kawarasaki T, Enya S, Otsu Y. The effect of estrogen administration during early pregnancy upon the survival of single implanted pig embryos. J Anim Sci. 2012 Dec;90(13):4781-7. doi: 10.2527/jas.2012-5178. Epub 2012 Jul 24. PubMed PMID: 22829621. 11: Noguchi M, Yoshioka K, Suzuki C, Itoh S, Kaneko H. An efficient protocol for inducing pseudopregnancy using estradiol dipropionate and follicular development associated with changes in reproductive hormones after prostaglandin F2alpha treatment in pseudopregnant sows. Reprod Biol Endocrinol. 2011 Dec 14;9:157. doi: 10.1186/1477-7827-9-157. PubMed PMID: 22168485; PubMed Central PMCID: PMC3286429. 12: Miyajima J, Hayashi T, Saito K, Iida S, Matsuoka K. The Interaction between female sex hormone receptors and osteopontin in a rat hyperoxaluric model. Kurume Med J. 2010;57(3):73-80. PubMed PMID: 21186342. 13: Noguchi M, Yoshioka K, Suzuki C, Arai S, Itoh S, Wada Y. Estrus synchronization with pseudopregnant gilts induced by a single treatment of estradiol dipropionate. J Reprod Dev. 2010 Aug;56(4):421-7. Epub 2010 May 19. PubMed PMID: 20484869. 14: Drekić D, Prostran MS, Duka M, Ranković V, Kerkez M, Stefanović D, Prostran MS. Study of molecular and granular layer of dentate gyrus of female rats neonatally treated with estrogen. Int J Neurosci. 2009;119(8):1228-38. PubMed PMID: 19922352. 15: Abdel-Dayem MM, Elgendy MS. Effects of chronic estradiol treatment on the thyroid gland structure and function of ovariectomized rats. BMC Res Notes. 2009 Aug 30;2:173. doi: 10.1186/1756-0500-2-173. PubMed PMID: 19715616; PubMed Central PMCID: PMC2743701. 16: Brzica H, Breljak D, Krick W, Lovrić M, Burckhardt G, Burckhardt BC, Sabolić I. The liver and kidney expression of sulfate anion transporter sat-1 in rats exhibits male-dominant gender differences. Pflugers Arch. 2009 Apr;457(6):1381-92. doi: 10.1007/s00424-008-0611-5. Epub 2008 Nov 11. PubMed PMID: 19002488. 17: Sekulić M, Sosić-Jurjević B, Filipović B, Nestorović N, Negić N, Stojanoski MM, Milosević V. Effect of estradiol and progesterone on thyroid gland in pigs: a histochemical, stereological, and ultrastructural study. Microsc Res Tech. 2007 Jan;70(1):44-9. PubMed PMID: 17019694. 18: Singh N, Malaviya B. Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat. Contraception. 2006 Jun;73(6):645-53. Epub 2006 Mar 20. PubMed PMID: 16730500. 19: Sekulić M, Sosić-Jurjević B, Filipović B, Manojlović-Stojanoski M, Milosević V. Immunoreactive TSH cells in juvenile and peripubertal rats after estradiol and human chorionic gonadotropin treatment. Acta Histochem. 2006;108(2):117-23. Epub 2006 May 22. PubMed PMID: 16714054. 20: Voznesenskaya TY, Blashkiv TV. Estradiol-dependent effect of nitric oxide on meiotic maturation of mouse oocytes. Bull Exp Biol Med. 2005 Oct;140(4):378-80. PubMed PMID: 16671556.