MedKoo Cat#: 562952 | Name: TC-E 5003
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.

Chemical Structure

TC-E 5003
TC-E 5003
CAS#17328-16-4

Theoretical Analysis

MedKoo Cat#: 562952

Name: TC-E 5003

CAS#: 17328-16-4

Chemical Formula: C16H14Cl2N2O4S

Exact Mass: 400.0051

Molecular Weight: 401.25

Elemental Analysis: C, 47.89; H, 3.52; Cl, 17.67; N, 6.98; O, 15.95; S, 7.99

Price and Availability

Size Price Availability Quantity
25mg USD 210.00
50mg USD 340.00
100mg USD 540.00
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Related CAS #
No Data
Synonym
TC-E 5003; TC E 5003; TCE 5003; TCE-5003; TCE5003;
IUPAC/Chemical Name
N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
InChi Key
SHRCVZJKZJGIHQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
SMILES Code
O=S(C1=CC=C(NC(CCl)=O)C=C1)(C2=CC=C(NC(CCl)=O)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen NY, Ng SY, Toepp SL, Ljubicic V. Protein arginine methyltransferase expression and activity during myogenesis. Biosci Rep. 2018 Jan 10;38(1). pii: BSR20171533. doi: 10.1042/BSR20171533. Print 2018 Feb 28. PubMed PMID: 29208765. 2: Bayen S, Saini S, Gaur P, Duraisamy AJ, Kumar Sharma A, Pal K, Vats P, Singh SB. PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model. Endocrine. 2018 Jan;59(1):151-163. doi: 10.1007/s12020-017-1463-6. Epub 2017 Nov 11. PubMed PMID: 29128891.