Synonym
Erbulozole; R 55104; R-55104; R55104;
IUPAC/Chemical Name
ethyl (4-((((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-methoxyphenyl)-1,3-dioxolan-4-yl)methyl)thio)phenyl)carbamate
InChi Key
KLEPCGBEXOCIGS-URXFXBBRSA-N
InChi Code
InChI=1S/C24H27N3O5S/c1-3-30-23(28)26-19-6-10-22(11-7-19)33-15-21-14-31-24(32-21,16-27-13-12-25-17-27)18-4-8-20(29-2)9-5-18/h4-13,17,21H,3,14-16H2,1-2H3,(H,26,28)/t21-,24-/m0/s1
SMILES Code
O=C(OCC)NC1=CC=C(SC[C@H]2O[C@](C3=CC=C(OC)C=C3)(CN4C=CN=C4)OC2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
469.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Van Belle SJ, Distelmans W, Vandebroek J, Bruynseels J, Van Ginckel R, Storme GA. Phase I trial of erbulozole (R55104). Anticancer Res. 1993 Nov-Dec;13(6B):2389-91. PubMed PMID: 8135472.
2: Distelmans W, Van Ginckel R, Vanherck W, Willebrords R, De Brabander M, Wouters L, Heeres J. Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989 Oct;25(10):1499-504. PubMed PMID: 2591442.
3: De Klippel N, De Keyser J, De Greve J, Van Belle S. A Wernicke's encephalopathy-like neurotoxicity induced by erbulozole. Neurology. 1991 May;41(5):762-3. PubMed PMID: 2027502.
4: Distelmans W, Van Ginckel R, Vanherck W, Willebrords R, Wouters L, De Brabander M, Mesens J. Erbulozole (P.I.N.N.) (R 55 104) encapsulated into cyclodextrins: has it a combined antitumoral and radioprotective potential? Anticancer Res. 1991 Jan-Feb;11(1):253-6. PubMed PMID: 2018359.
