MedKoo Cat#: 561665 | Name: TC-DAPK 6
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-DAPK 6 is a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor.

Chemical Structure

TC-DAPK 6
TC-DAPK 6
CAS#315694-89-4

Theoretical Analysis

MedKoo Cat#: 561665

Name: TC-DAPK 6

CAS#: 315694-89-4

Chemical Formula: C17H12N2O2

Exact Mass: 276.0899

Molecular Weight: 276.29

Elemental Analysis: C, 73.90; H, 4.38; N, 10.14; O, 11.58

Price and Availability

Size Price Availability Quantity
10mg USD 250.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
TC-DAPK 6; TC DAPK 6; TCDAPK6; TC-DAPK6; DAPK Inhibitor; T6908224; T-6908224; T 6908224;
IUPAC/Chemical Name
(4Z)-2-[2-Phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
InChi Key
GFGMISOSPOPSHN-NOCYUORASA-N
InChi Code
InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
SMILES Code
O=C(OC(/C=C/C1=CC=CC=C1)=N/2)C2=C\C3=CC=CN=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Okamoto M, Takayama K, Shimizu T, Ishida K, Takahashi O, Furuya T. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7. doi: 10.1021/jm901191q. PubMed PMID: 19877644. Zhang J, Zhang J, Zhou B, Jiang X, Tang Y, Zhang Z. Death-Associated Protein Kinase 1 (DAPK1) Protects against Myocardial Injury Induced by Myocardial Infarction in Rats via Inhibition of Inflammation and Oxidative Stress. Dis Markers. 2022 Jan 17;2022:9651092. doi: 10.1155/2022/9651092. PMID: 35082934; PMCID: PMC8786546. Li T, Wu YN, Wang H, Ma JY, Zhai SS, Duan J. Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway. Mol Immunol. 2020 Apr;120:13-22. doi: 10.1016/j.molimm.2020.01.014. Epub 2020 Feb 8. PMID: 32045770.