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MedKoo Cat#: 596761 | Name: Liothyronine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Liothyronine is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

Chemical Structure

Liothyronine HCl
CAS#6138-47-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 596761

Name: Liothyronine HCl

CAS#: 6138-47-2 (HCl)

Chemical Formula: C15H13ClI3NO4

Exact Mass: 0.0000

Molecular Weight: 687.44

Elemental Analysis: C, 26.21; H, 1.91; Cl, 5.16; I, 55.38; N, 2.04; O, 9.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
55-06-1 (sodium) 6138-47-2 (HCl) 6893-02-3 (free)
Synonym
Liothyronine HCl; Liothyronine hydrochloride; L-Liothyronine; L-T3; Liotironina; Triiodothyronine; NSC 80203; NSC-80203; NSC80203;
IUPAC/Chemical Name
(S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid hydrochloride
InChi Key
HFEMPWKWYHWPQX-YDALLXLXSA-N
InChi Code
InChI=1S/C15H12I3NO4.ClH/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);1H/t12-;/m0./s1
SMILES Code
O=C(O)[C@@H](N)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 687.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 27864708. 11: Bunevicius A, Laws ER, Deltuva V, Tamasauskas A. Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study. J Neurooncol. 2017 Jan;131(2):385-391. doi: 10.1007/s11060-016-2311-x. Epub 2016 Nov 9. PubMed PMID: 27830477. 12: Jeong HS, Choi EK, Song IU, Chung YA, Park JS, Oh JK. Differences in Brain Glucose Metabolism During Preparation for (131)I Ablation in Thyroid Cancer Patients: Thyroid Hormone Withdrawal Versus Recombinant Human Thyrotropin. Thyroid. 2017 Jan;27(1):23-28. doi: 10.1089/thy.2016.0293. Epub 2016 Nov 28. PubMed PMID: 27774839. 13: Zhang X, Yao B, Li C, Mao J, Wang W, Xie X, Teng X, Han C, Zhou W, Li C, Xu B, Bi L, Meng T, Du J, Zhang S, Gao Z, Yang L, Fan C, Teng W, Shan Z. Reference Intervals of Thyroid Function During Pregnancy: Self-Sequential Longitudinal Study Versus Cross-Sectional Study. Thyroid. 2016 Dec;26(12):1786-1793. Epub 2016 Nov 8. 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