Liothyronine | CAS#6893-02-3 | T3 thyroid hormone

MedKoo Cat#: 596508 | Name: Liothyronine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Liothyronine is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

Chemical Structure

Liothyronine

CAS#6893-02-3 (free)

Theoretical Analysis

MedKoo Cat#: 596508

Name: Liothyronine

CAS#: 6893-02-3 (free)

Chemical Formula: C15H12I3NO4

Exact Mass: 650.7900

Molecular Weight: 650.98

Elemental Analysis: C, 27.68; H, 1.86; I, 58.48; N, 2.15; O, 9.83

Price and Availability

Size	Price	Availability
250mg	USD 90.00	Ready to ship
500mg	USD 150.00	Ready to ship
1g	USD 250.00	Ready to ship
2g	USD 450.00	Ready to ship
5g	USD 950.00	2 Weeks

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Related CAS #

55-06-1 (sodium) 6138-47-2 (HCl) 6893-02-3 (free)

Synonym

Liothyronine; L-Liothyronine; L-T3; Liotironina; Triiodothyronine; NSC 80203; NSC-80203; NSC80203;

IUPAC/Chemical Name

(S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid

InChi Key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

InChi Code

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

SMILES Code

N[C@@H](CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.

In vitro activity:

A one-week treatment with T3 increased cardiomyocyte size, anisotropy, and sarcomere length. T3 treatment was associated with reduced cell cycle activity, manifest as reduced DNA synthesis and increased expression of the cyclin-dependent kinase inhibitor p21. Reference: J Mol Cell Cardiol. 2014 Jul;72:296-304. https://pubmed.ncbi.nlm.nih.gov/24735830/

In vivo activity:

The systemic immune response was also explored, and low dose of liothyronine could significantly elicit immune responses by increasing the frequency of CD8+ IFN-γ+ T cells in the tumor draining lymph node but not in the spleen, while high dose of liothyronine could increase the frequency in both tissues (Fig. 6d, e). Thus, liothyronine could suppress tumor growth and stimulate CD8+ T cell response in tumor bearing mice. Reference: Cell Commun Signal. 2020 Sep 7;18(1):142. https://pubmed.ncbi.nlm.nih.gov/32894141/

	Solvent	mg/mL	mM	comments
Solubility
	DMSO:PBS (pH 7.2) (1:6)	0.1	0.22

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 650.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Pourzardosht N, Hashemi ZS, Mard-Soltani M, Jahangiri A, Rahbar MR, Zakeri A, Mirzajani E, Khalili S. Liothyronine could block the programmed death-ligand 1 (PDL1) activity: an e-Pharmacophore modeling and virtual screening study. J Recept Signal Transduct Res. 2022 Feb;42(1):34-42. doi: 10.1080/10799893.2020.1839765. Epub 2020 Oct 26. PMID: 33100099. 2. Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, Sniadecki NJ, Ruohola-Baker H, Murry CE. Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells. J Mol Cell Cardiol. 2014 Jul;72:296-304. doi: 10.1016/j.yjmcc.2014.04.005. Epub 2014 Apr 13. PMID: 24735830; PMCID: PMC4041732. 3. Zhou X, Du J, Wang H, Chen C, Jiao L, Cheng X, Zhou X, Chen S, Gou S, Zhao W, Zhai W, Chen J, Gao Y. Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR. Cell Commun Signal. 2020 Sep 7;18(1):142. doi: 10.1186/s12964-020-00638-2. PMID: 32894141; PMCID: PMC7487564.

In vitro protocol:

In vivo protocol:

1. Zhou X, Du J, Wang H, Chen C, Jiao L, Cheng X, Zhou X, Chen S, Gou S, Zhao W, Zhai W, Chen J, Gao Y. Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR. Cell Commun Signal. 2020 Sep 7;18(1):142. doi: 10.1186/s12964-020-00638-2. PMID: 32894141; PMCID: PMC7487564.

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