Synonym
Spizofurone; Espizofurona
IUPAC/Chemical Name
5-Acetylspiro(benzofuran-2(3H),1'-cyclopropan)-3-one
InChi Key
SETMGIIITGNLAS-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10O3/c1-7(13)8-2-3-10-9(6-8)11(14)12(15-10)4-5-12/h2-3,6H,4-5H2,1H3
SMILES Code
O=C1C2(CC2)OC3=CC=C(C(C)=O)C=C13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
202.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Felman SW, Jirkovsky I, Memoli KA, Borella L, Wells C, Russell J, Ward J. Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)-furanones. J Med Chem. 1992 Apr 3;35(7):1183-90. PubMed PMID: 1560433.
2: Kohda I, Nagai H, Iwai M, Watanabe M, Yokoyama K, Tsujikawa K, Mimura T. Effects of 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide on various ulcer models in rats. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1828-31. PubMed PMID: 1777936.
3: Yamahara J, Mochizuki M, Fujimura H, Takaishi Y, Yoshida M, Tomimatsu T, Tamai Y. Antiulcer action of Sophora flavescens root and an active constituent. I. J Ethnopharmacol. 1990 May;29(2):173-7. PubMed PMID: 2374430.
4: Inada I, Satoh H, Inatomi N, Nagaya H, Maki Y. Spizofurone, a new anti-ulcer agent, increases alkaline secretion in isolated bullfrog duodenal mucosa. Eur J Pharmacol. 1986 May 13;124(1-2):149-55. PubMed PMID: 2424775.
5: Inatomi N, Satoh H, Inada I, Hirata T, Nagaya H, Maki Y. Gastric mucosal protection by spizofurone. Eur J Pharmacol. 1985 May 28;112(1):81-7. PubMed PMID: 3860385.
6: Inatomi N, Satoh H, Nagaya H, Maki Y. Spizofurone (AG-629) increases gastric mucosal blood flow in dogs: a possible mechanism of its anti-ulcer effect. Eur J Pharmacol. 1985 Apr 16;110(3):343-50. PubMed PMID: 3859418.
7: Inatomi N, Hirata T, Inada I, Satoh H, Sino A, Maki Y. Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. Arzneimittelforschung. 1985;35(10):1553-9. PubMed PMID: 4074415.
