L-770644 | CAS#173901-95-6 | B3 adrenergic receptor agonist

MedKoo Cat#: 596694 | Name: L-770644

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-770644 is a B3 adrenergic receptor agonist.

Chemical Structure

L-770644

CAS#173901-95-6

Theoretical Analysis

MedKoo Cat#: 596694

Name: L-770644

CAS#: 173901-95-6

Chemical Formula: C30H37N7O4S

Exact Mass: 591.2628

Molecular Weight: 591.73

Elemental Analysis: C, 60.89; H, 6.30; N, 16.57; O, 10.82; S, 5.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L-770644; L 770644; L770644;

IUPAC/Chemical Name

(R)-4-(4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-N-(4-(2-((2-hydroxy-2-(pyridin-3-yl)ethyl)amino)ethyl)phenyl)benzenesulfonamide

InChi Key

GCRTUWDFTYDUFB-LJAQVGFWSA-N

InChi Code

InChI=1S/C30H37N7O4S/c38-29(25-8-3-18-31-21-25)22-32-19-17-24-9-11-26(12-10-24)33-42(40,41)28-15-13-27(14-16-28)37-30(39)36(34-35-37)20-4-7-23-5-1-2-6-23/h3,8-16,18,21,23,29,32-33,38H,1-2,4-7,17,19-20,22H2/t29-/m0/s1

SMILES Code

O=S(C1=CC=C(N2N=NN(CCCC3CCCC3)C2=O)C=C1)(NC4=CC=C(CCNC[C@H](O)C5=CC=CN=C5)C=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 591.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Colwell LF Jr, Tamvakopoulos CS, Wang PR, Pivnichny JV, Shih TL. Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25;772(1):89-98. PubMed PMID: 12016019. 2: Shih TL, Candelore MR, Cascieri MA, Chiu SH, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L, Wyvratt MJ, Fisher MH, Weber AE. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. PubMed PMID: 10340609.