Synonym
Acetabuton; Aceperone
IUPAC/Chemical Name
4-(4-(Acetamidomethyl)-4-phenylpiperidino)-4'-fluorobutyrophenone
InChi Key
VDGZERMDPAAZEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28)
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCC(C3=CC=CC=C3)(CNC(C)=O)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
396.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Braestrup C. Effects of phenoxybenzamine, aceperone and clonidine on the level of 3-methoxy-4-hydroxyphenylglycol (MOPEG) in rat brain. J Pharm Pharmacol. 1974 Feb;26(2):139-41. PubMed PMID: 4150833.
2: Quaglio MP, Bellini AM. A gas chromatographic method for the determination of fluanisone, moperone, aceperone and pipamperone in human plasma. Farmaco Prat. 1981 Apr;36(4):204-14. PubMed PMID: 6112157.
3: Scheel-Krüger J. Studies on the accumulation of O-methylated dopamine and noradrenaline in the rat brain following various neuroleptics, thymoleptics and aceperone. Arch Int Pharmacodyn Ther. 1972 Feb;195(2):372-8. PubMed PMID: 5015941.
4: Baker HF, Ridley RM, Haystead TA, Crow TJ. Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and colour discrimination and on an alternation task. Pharmacol Biochem Behav. 1983 May;18(5):701-4. PubMed PMID: 6222386.
5: Zebrowska-Lupina I. The effect of alpha-adrenolytics on central action of agonists and antagonists of dopaminergic system. Pol J Pharmacol Pharm. 1977 Jul-Aug;29(4):393-404. PubMed PMID: 20609.
6: Ridley RM, Haystead TA, Baker HF, Crow TJ. A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade. Pharmacol Biochem Behav. 1981 Jun;14(6):849-55. PubMed PMID: 6114497.
7: Scraggs PR, Ridley RM. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology (Berl). 1979 Mar 29;62(1):41-5. PubMed PMID: 155838.
8: Braestrup C, Nielsen M. Regulation in the central norepinephrine neurotransmission induced in vivo by alpha adrenoceptor active drugs. J Pharmacol Exp Ther. 1976 Sep;198(3):596-608. PubMed PMID: 185355.
9: Zebrowska-Lupina I. Studies on the mechanisms of central action of alpha-adrenergic receptor blocking agents. Pol J Pharmacol Pharm. 1978 Jul-Aug;30(4):455-8. PubMed PMID: 33369.
10: Zebrowska-Lupina I, Przegalinski E, Sloniec M, Kleinrok Z. Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic alpha-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1977 Apr;297(3):227-31. PubMed PMID: 69273.
11: Costall B, Naylor RJ. Antagonism of the hyperactivity induced by dopamine applied intracerebrally to the nucleus accumbens septi by typical neuroleptics and by clozapine, sulpiride and thioridazine. Eur J Pharmacol. 1976 Jan;35(1):161-8. PubMed PMID: 1253817.
12: Costall B, Naylor RJ, Pinder RM. Hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens. Eur J Pharmacol. 1976 Sep;39(1):153-60. PubMed PMID: 134899.
13: Fidecka S, Langwiński R. Central action of narcotic analgesics. Part III. The role of endogenous noradrenaline in hyperactivity induced by morphine or fentanyl in mice. Pol J Pharmacol Pharm. 1978 Jul-Aug;30(4):537-47. PubMed PMID: 216979.
14: Hwang EC, Van Woert MH. DDT-induced myoclonus: serotonin and alpha noradrenergic interaction. Res Commun Chem Pathol Pharmacol. 1979 Feb;23(2):257-66. PubMed PMID: 37558.
15: Zebrowska-Lupina I. Analgesic action of alpha-adrenolytics in albino mice. Pol J Pharmacol Pharm. 1977 Mar-Apr;29(2):101-9. PubMed PMID: 16252.
16: Martin GE, Papp NL. Blockade of MK-801 induced ipsiversive turning in 6-OHDA lesioned rats by alpha 1-adrenoceptor antagonists. Pharmacol Biochem Behav. 1984 Jun;20(6):893-7. PubMed PMID: 6146989.
17: Lassen JB. Inhibition and potentiation of apomorphine-induced hypermotility in rats by neuroleptics. Eur J Pharmacol. 1976 Apr;36(2):385-93. PubMed PMID: 1278230.
18: Owen RT. Intrastriatal kainic acid- a possible model for antidyskinetic/antichoreic agents? Methods Find Exp Clin Pharmacol. 1980 Apr;2(3):133-7. PubMed PMID: 7339335.
19: Byrska B, Reichenberg K, Romańska I, Vetulani J. Behavioral and biochemical effects of intraventricular kainic acid. Pol J Pharmacol Pharm. 1980 Jul-Aug;32(4):531-8. PubMed PMID: 6265888.
20: Przegaliński E, Zebrowska-Lupina I, Wójcik A, Kleinrok Z. 5-Methoxytryptamine-induced head twitches in rats. Pol J Pharmacol Pharm. 1977 May-Jun;29(3):253-61. PubMed PMID: 267911.
