L-771688 | SNAP-6383 | CAS#200050-59-5 | 200051-19-0 | α1A-adrenoceptor antagonist

MedKoo Cat#: 530418 | Name: L-771688

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-771688, also known as SNAP-6383, is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia. L-771,688 had high affinity (Ki less than or = 1 nM) for [3H]prazosin binding to cloned human, rat and dog alpha1A-adrenoceptors and high selectivity (>500-fold) over alpha1B and alpha1D-adrenoceptors. L-771,688 is a highly selective alpha1A-adrenoceptor antagonist.

Chemical Structure

L-771688

CAS#200050-59-5

Theoretical Analysis

MedKoo Cat#: 530418

Name: L-771688

CAS#: 200050-59-5

Chemical Formula: C28H33F2N5O5

Exact Mass: 557.2450

Molecular Weight: 557.60

Elemental Analysis: C, 60.31; H, 5.97; F, 6.81; N, 12.56; O, 14.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

200051-19-0 (dichloride);

Synonym

L-771688; SNAP-6383; L 771688; SNAP 6383; L771688; SNAP6383.

IUPAC/Chemical Name

methyl (S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-((3-(4-(pyridin-2-yl)piperidin-1-yl)propyl)carbamoyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

InChi Key

FFXFCSQUTLDLAR-VWLOTQADSA-N

InChi Code

InChI=1S/C28H33F2N5O5/c1-39-17-23-24(26(36)40-2)25(19-7-8-20(29)21(30)16-19)35(28(38)33-23)27(37)32-12-5-13-34-14-9-18(10-15-34)22-6-3-4-11-31-22/h3-4,6-8,11,16,18,25H,5,9-10,12-15,17H2,1-2H3,(H,32,37)(H,33,38)/t25-/m0/s1

SMILES Code

O=C(C1=C(COC)NC(N(C(NCCCN2CCC(C3=NC=CC=C3)CC2)=O)[C@H]1C4=CC=C(F)C(F)=C4)=O)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 200050-59-5 (L-771688 free base) 200051-19-0 (L-771688 dihydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 557.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xu F, Huang D, Lin X, Wang Y. Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids. Org Biomol Chem. 2012 Jun 14;10(22):4467-70. doi: 10.1039/c2ob25663k. PubMed PMID: 22565820. 2: Li N, Chen XH, Song J, Luo SW, Fan W, Gong LZ. Highly enantioselective organocatalytic Biginelli and Biginelli-like condensations: reversal of the stereochemistry by tuning the 3,3'-disubstituents of phosphoric acids. J Am Chem Soc. 2009 Oct 28;131(42):15301-10. doi: 10.1021/ja905320q. Erratum in: J Am Chem Soc. 2010 Aug 11;132(31):10953. PubMed PMID: 19785440. 3: Winchell GA, Mistry GC, Kari PP, Marbury T, Miller JL, Simpson RC, Rodrigues AD, Gottesdiener KM, Wagner JA. The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. J Clin Pharmacol. 2005 Jun;45(6):699-703. PubMed PMID: 15901753. 4: Chang RS, Chen TB, O'Malley SS, Pettibone DJ, DiSalvo J, Francis B, Bock MG, Freidinger R, Nagarathnam D, Miao SW, Shen Q, Lagu B, Murali Dhar TG, Tyagarajan S, Marzabadi MR, Wong WC, Gluchowski C, Forray C. In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J Pharmacol. 2000 Dec 15;409(3):301-12. PubMed PMID: 11108825.