DS44960156 is a potent and selective MTHFD2 Inhibitor. DS44960156 would offer a good starting point for further optimization based on the following features: (1) unprecedented selectivity (>18-fold) for MTHFD2 over MTHFD1, (2) a molecular weight of less than 400, and (3) good ligand efficiency (LE).
MedKoo Cat#: 555553
Name: DS44960156
CAS#: Unknown
Chemical Formula: C20H15NO5
Exact Mass: 349.0950
Molecular Weight: 349.34
Elemental Analysis: C, 68.76; H, 4.33; N, 4.01; O, 22.90
The following data is based on the product molecular weight 349.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
