L 708286 | CAS#119720-81-9 | peptide-based phenethylcarbamoyldifluoromethylene

MedKoo Cat#: 596669 | Name: L 708286

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 708286 is a peptide-based phenethylcarbamoyldifluoromethylene compound; slow-binding inhibitor of human leucocyte elastase (HLE).

Chemical Structure

L 708286

CAS#119720-81-9

Theoretical Analysis

MedKoo Cat#: 596669

Name: L 708286

CAS#: 119720-81-9

Chemical Formula: C25H34F2N4O5

Exact Mass: 508.2497

Molecular Weight: 508.56

Elemental Analysis: C, 59.04; H, 6.74; F, 7.47; N, 11.02; O, 15.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 708286; L-708286; L708286; DFKi;

IUPAC/Chemical Name

(S)-1-(acetyl-L-alanyl)-N-((S)-5,5-difluoro-2-methyl-4,6-dioxo-6-(phenethylamino)hexan-3-yl)pyrrolidine-2-carboxamide

InChi Key

DIDRITFKGCLDSK-VDGAXYAQSA-N

InChi Code

InChI=1S/C25H34F2N4O5/c1-15(2)20(21(33)25(26,27)24(36)28-13-12-18-9-6-5-7-10-18)30-22(34)19-11-8-14-31(19)23(35)16(3)29-17(4)32/h5-7,9-10,15-16,19-20H,8,11-14H2,1-4H3,(H,28,36)(H,29,32)(H,30,34)/t16-,19-,20-/m0/s1

SMILES Code

O=C(N[C@@H](C(C)C)C(C(F)(F)C(NCCC1=CC=CC=C1)=O)=O)[C@H]2N(C([C@H](C)NC(C)=O)=O)CCC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 508.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang L, Song L, Terracina G, Liu Y, Pramanik B, Parker E. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. Biochemistry. 2001 Apr 24;40(16):5049-55. PubMed PMID: 11305921. 2: Masek BB, Merchant A, Matthew JB. Molecular skins: a new concept for quantitative shape matching of a protein with its small molecule mimics. Proteins. 1993 Oct;17(2):193-202. PubMed PMID: 8265566. 3: Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green BG, Chabin R, et al. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Biochemistry. 1993 Mar 2;32(8):2031-5. PubMed PMID: 8095408.