J27 | NF-κB/MAPK inhibitor

MedKoo Cat#: 124749 | Name: J27

Description:

WARNING: This product is for research use only, not for human or veterinary use.

J27 is a NF-κB/MAPK inhibitor. J27decreased the release of TNF-αandIL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC50= 0.22μM )through the NF-κB/MAPK pathway. J27 demonstrated remarkable protection against ALI and sepsis in vivo and exhibited good safety in subacute toxicity experiments. Pharmacokinetic study indicated that J27 had good bioavailability (30.74%).To oursurprise,J27 could targe tJNK2 with a totally new molecular skeleton compared with the only few JNK2 inhibitors reported. Moreover, there is no reportthat JNK2 inhibitors could apply for ALI and sepsis.Therefore, this work provides a new lead structure for the study of JNK2inhibitorsanda new target of JNK2to treat ALI and sepsis.

Chemical Structure

J27

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124749

Name: J27

CAS#: N/A

Chemical Formula: C30H26N4O5

Exact Mass: 522.1900

Molecular Weight: 522.56

Elemental Analysis: C, 68.95; H, 5.02; N, 10.72; O, 15.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

J27; J 27; J-27

IUPAC/Chemical Name

N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide

InChi Key

RHGFVWDZWMEFNR-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H26N4O5/c1-18-5-9-21(10-6-18)34-28(35)15-19(2)29(33-34)30(36)32-20-7-11-22(12-8-20)39-25-13-14-31-24-17-27(38-4)26(37-3)16-23(24)25/h5-17H,1-4H3,(H,32,36)

SMILES Code

CC1=CC(N(C2=CC=C(C)C=C2)N=C1C(NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C54)C=C3)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 522.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liao J, Yang J, Li X, Hu C, Zhu W, Zhou Y, Zou Y, Guo M, Chen Z, Li X, Dai J, Xu Y, Zheng Z, Chen P, Cho WJ, Liang G, Tang Q. Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway. J Med Chem. 2023 Aug 29. doi: 10.1021/acs.jmedchem.3c00832. Epub ahead of print. PMID: 37643372. 2: Cuevas-González PF, Aguilar-Toalá JE, García HS, González-Córdova AF, Vallejo-Cordoba B, Hernández-Mendoza A. Protective Effect of the Intracellular Content from Potential Probiotic Bacteria against Oxidative Damage Induced by Acrylamide in Human Erythrocytes. Probiotics Antimicrob Proteins. 2020 Dec;12(4):1459-1470. doi: 10.1007/s12602-020-09636-9. PMID: 31970648. 3: Bhatt JD, Chudasama CJ, Patel KD. Diarylpyrazole Ligated Dihydropyrimidine Hybrids as Potent Non-Classical Antifolates and Their Efficacy Against Plasmodium falciparum. Arch Pharm (Weinheim). 2017 Sep;350(9). doi: 10.1002/ardp.201700088. Epub 2017 Aug 10. PMID: 28796406. 4: Bhatt JD, Chudasama CJ, Patel KD. Microwave Assisted Synthesis of Pyrimidines in Ionic Liquid and Their Potency as Non-Classical Malarial Antifolates. Arch Pharm (Weinheim). 2016 Oct;349(10):791-800. doi: 10.1002/ardp.201600148. Epub 2016 Aug 16. PMID: 27528517.