1M7 | CAS#4693-01-0 | RNA SHAPE reagent

MedKoo Cat#: 527688 | Name: 1M7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

1M7 is an RNA SHAPE reagent.

Chemical Structure

1M7

CAS#4693-01-0

Theoretical Analysis

MedKoo Cat#: 527688

Name: 1M7

CAS#: 4693-01-0

Chemical Formula: C9H7N2O5

Exact Mass: 223.0355

Molecular Weight: 223.16

Elemental Analysis: C, 48.44; H, 3.16; N, 12.55; O, 35.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

1M 7; 1M-7; 1M7

IUPAC/Chemical Name

1-methyl-5-nitro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

InChi Key

FJSZPPSFHYCQHQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H6N2O5/c1-10-5-3-2-4-6(11(14)15)7(5)8(12)16-9(10)13/h2-4H,1H3

SMILES Code

O=C(O1)C2=C(N(C)C1=O)C=CC=C2[N+]([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 223.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Roston TM, Dewar L, Franciosi S, Hathaway J, Bartels K, Cunningham T, Gibbs KA, Sheps S, Laksman ZWM, Sanatani S, Krahn AD. The accessibility and utilization of genetic testing for inherited heart rhythm disorders: a Canadian cross-sectional survey study. J Community Genet. 2017 Nov 23. doi: 10.1007/s12687-017-0348-y. [Epub ahead of print] PubMed PMID: 29170972. 2: Busan S, Weeks KM. Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2. RNA. 2018 Feb;24(2):143-148. doi: 10.1261/rna.061945.117. Epub 2017 Nov 7. PubMed PMID: 29114018. 3: Stanford K, Reuter T, Bach SJ, Chui L, Ma A, Conrad CC, Tostes R, McAllister TA. Effect of severe weather events on the shedding of Shiga toxigenic Escherichia coli in slaughter cattle and phenotype of serogroup O157 isolates. FEMS Microbiol Ecol. 2017 Sep 1;93(9). doi: 10.1093/femsec/fix098. PubMed PMID: 28922801. 4: Nwachokor J, Tawfik O, Danley M, Mathur S, House J, Sharma P, Christenson LK, Bansal A. Quantitation of spatial and temporal variability of biomarkers for Barrett's Esophagus. Dis Esophagus. 2017 Sep 1;30(9):1-8. doi: 10.1093/dote/dox023. PubMed PMID: 28859356. 5: Shariati H, Armstrong HL, Cui Z, Lachowsky NJ, Zhu J, Anand P, Roth EA, Hogg RS, Oudman G, Tonella C, Moore DM. Changes in smoking status among a longitudinal cohort of gay, bisexual, and other men who have sex with men in Vancouver, Canada. Drug Alcohol Depend. 2017 Oct 1;179:370-378. doi: 10.1016/j.drugalcdep.2017.07.025. Epub 2017 Aug 16. PubMed PMID: 28844014. 6: Lee JH, Protze SI, Laksman Z, Backx PH, Keller GM. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017 Aug 3;21(2):179-194.e4. doi: 10.1016/j.stem.2017.07.003. PubMed PMID: 28777944. 7: Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry. Europace. 2017 Jan 31. doi: 10.1093/europace/euw389. [Epub ahead of print] PubMed PMID: 28158428. 8: Lee B, Flynn RA, Kadina A, Guo JK, Kool ET, Chang HY. Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA. 2017 Feb;23(2):169-174. doi: 10.1261/rna.058784.116. Epub 2016 Nov 22. PubMed PMID: 27879433; PubMed Central PMCID: PMC5238792. 9: Steinberg C, Padfield GJ, Al-Sabeq B, Adler A, Yeung-Lai-Wah JA, Kerr CR, Deyell MW, Andrade JG, Bennett MT, Yee R, Klein GJ, Green M, Laksman ZW, Krahn AD, Chakrabarti S. Experience with bisoprolol in long-QT1 and long-QT2 syndrome. J Interv Card Electrophysiol. 2016 Nov;47(2):163-170. Epub 2016 Jul 9. PubMed PMID: 27394160. 10: Hajizadeh M, Mitnitski A, Rockwood K. Socioeconomic gradient in health in Canada: Is the gap widening or narrowing? Health Policy. 2016 Sep;120(9):1040-50. doi: 10.1016/j.healthpol.2016.07.019. Epub 2016 Aug 3. PubMed PMID: 27523425. 11: Parker SI, Benzies KM, Hayden KA, Lang ES. Effectiveness of interventions for adult peripheral intravenous catheterization: A systematic review and meta-analysis of randomized controlled trials. Int Emerg Nurs. 2017 Mar;31:15-21. doi: 10.1016/j.ienj.2016.05.004. Epub 2016 Jul 11. Review. PubMed PMID: 27411965. 12: García-Guerra A, Waldner CL, Pellegrino A, Macdonald N, Chaban B, Hill JE, Hendrick SH. Effect of sample pooling and transport conditions on the clinical sensitivity of a real-time polymerase chain reaction assay for Campylobacter fetus subsp. venerealis in preputial samples from bulls. Can J Vet Res. 2016 Jan;80(1):32-9. PubMed PMID: 26733730; PubMed Central PMCID: PMC4686032. 13: Birnie D, Ha AC, Gula LJ, Chakrabarti S, Beanlands RS, Nery P. Cardiac Sarcoidosis. Clin Chest Med. 2015 Dec;36(4):657-68. doi: 10.1016/j.ccm.2015.08.008. Epub 2015 Sep 11. Review. PubMed PMID: 26593140. 14: Coughlin RP, Pauyo T, Sutton JC 3rd, Coughlin LP, Bergeron SG. A Validated Orthopaedic Surgical Simulation Model for Training and Evaluation of Basic Arthroscopic Skills. J Bone Joint Surg Am. 2015 Sep 2;97(17):1465-71. doi: 10.2106/JBJS.N.01140. PubMed PMID: 26333743. 15: Cheng A, Lockey A, Bhanji F, Lin Y, Hunt EA, Lang E. The use of high-fidelity manikins for advanced life support training--A systematic review and meta-analysis. Resuscitation. 2015 Aug;93:142-9. doi: 10.1016/j.resuscitation.2015.04.004. Epub 2015 Apr 14. Review. PubMed PMID: 25888241. 16: Tildesley HD, Po MD, Ross SA. Internet blood glucose monitoring systems provide lasting glycemic benefit in type 1 and 2 diabetes: a systematic review. Med Clin North Am. 2015 Jan;99(1):17-33. doi: 10.1016/j.mcna.2014.08.019. Epub 2014 Oct 18. Review. PubMed PMID: 25456641. 17: Rice GM, Leonard CW, Weeks KM. RNA secondary structure modeling at consistent high accuracy using differential SHAPE. RNA. 2014 Jun;20(6):846-54. doi: 10.1261/rna.043323.113. Epub 2014 Apr 17. PubMed PMID: 24742934; PubMed Central PMCID: PMC4024639. 18: Kim YM, Choi WY, Oh CM, Han GH, Kim YJ. Secondary structure of the Irf7 5'-UTR, analyzed using SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension). BMB Rep. 2014 Oct;47(10):558-62. PubMed PMID: 24393529; PubMed Central PMCID: PMC4261513. 19: Turner R, Shefer K, Ares M Jr. Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7). RNA. 2013 Dec;19(12):1857-63. doi: 10.1261/rna.042374.113. Epub 2013 Oct 18. PubMed PMID: 24141619; PubMed Central PMCID: PMC3884660. 20: Curial M, Nath E, Lang E. Novel antiplatelet agent use for acute coronary syndrome in the emergency department: a review. Cardiol Res Pract. 2013;2013:127270. doi: 10.1155/2013/127270. Epub 2013 Feb 21. PubMed PMID: 23509665; PubMed Central PMCID: PMC3594944.