AG 879 | CAS#148741-30-4

MedKoo Cat#: 524142 | Name: AG 879

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.

Chemical Structure

AG 879

CAS#148741-30-4

Theoretical Analysis

MedKoo Cat#: 524142

Name: AG 879

CAS#: 148741-30-4

Chemical Formula: C18H24N2OS

Exact Mass: 316.1609

Molecular Weight: 316.46

Elemental Analysis: C, 68.32; H, 7.64; N, 8.85; O, 5.06; S, 10.13

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 2,850.00	2 Weeks
2g	USD 4,650.00	2 Weeks

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Related CAS #

No Data

Synonym

AG 879; AG879; AG-879; Tyrphostin AG 879;

IUPAC/Chemical Name

2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

InChi Key

XRZYELWZLNAXGE-KPKJPENVSA-N

InChi Code

InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

SMILES Code

S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: He Y, Pan Z, Liu Y, Jiang L, Peng H, Zhao P, Qi Z, Liu Y, Tang H. Identification of tyrphostin AG879 and A9 inhibiting replication of chikungunya virus by screening of a kinase inhibitor library. Virology. 2023 Nov;588:109900. doi: 10.1016/j.virol.2023.109900. Epub 2023 Oct 7. PMID: 37832343. 2: Coulet M, Lachkar S, Leduc M, Trombe M, Gouveia Z, Perez F, Kepp O, Kroemer G, Basmaciogullari S. Identification of Small Molecules Affecting the Secretion of Therapeutic Antibodies with the Retention Using Selective Hook (RUSH) System. Cells. 2023 Jun 16;12(12):1642. doi: 10.3390/cells12121642. PMID: 37371112; PMCID: PMC10297138. 3: Karthikeyan S, Sundaramoorthy A, Kandasamy S, Bharanidharan G, Aruna P, Suganya R, Mangaiyarkarasi R, Ganesan S, Pandian GN, Ramamoorthi A, Chinnathambi S. A biophysical approach of tyrphostin AG879 binding information in: bovine serum albumin, human ErbB2, c-RAF1 kinase, SARS-CoV-2 main protease and angiotensin-converting enzyme 2. J Biomol Struct Dyn. 2024 Feb- Mar;42(3):1455-1468. doi: 10.1080/07391102.2023.2204368. Epub 2023 Apr 28. PMID: 37114656. 4: Erkin ÖC, Cömertpay B, Göv E. Integrative Analysis for Identification of Therapeutic Targets and Prognostic Signatures in Non-Small Cell Lung Cancer. Bioinform Biol Insights. 2022 Apr 6;16:11779322221088796. doi: 10.1177/11779322221088796. PMID: 35422618; PMCID: PMC9003654. 5: Zoeller RA, Geoghegan-Barek K. A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. Biochem Biophys Rep. 2019 Mar 6;18:100621. doi: 10.1016/j.bbrep.2019.100621. Erratum in: Biochem Biophys Rep. 2021 Jan 07;25:100901. doi: 10.1016/j.bbrep.2020.100901. PMID: 30899803; PMCID: PMC6406593. 6: Miladinovic T, Ungard RG, Linher-Melville K, Popovic S, Singh G. Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain. 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PMID: 26440329. 9: Kumar V, Gupta AK, Shukla RK, Tripathi VK, Jahan S, Pandey A, Srivastava A, Agrawal M, Yadav S, Khanna VK, Pant AB. Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity. Sci Rep. 2015 Sep 15;5:14038. doi: 10.1038/srep14038. Erratum in: Sci Rep. 2020 Apr 20;10(1):6909. doi: 10.1038/s41598-020-63175-5. PMID: 26370177; PMCID: PMC4570211. 10: Yu H, Zou B, Wang X, Li M. Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. Br J Pharmacol. 2015 Jul;172(13):3370-82. doi: 10.1111/bph.13127. Epub 2015 Apr 24. PMID: 25752739; PMCID: PMC4500372. 11: Arias ER, Valle-Leija P, Morales MA, Cifuentes F. Differential contribution of BDNF and NGF to long-term potentiation in the superior cervical ganglion of the rat. Neuropharmacology. 2014 Jun;81:206-14. doi: 10.1016/j.neuropharm.2014.02.001. Epub 2014 Feb 11. PMID: 24530966. 12: Callaghan CK, Kelly AM. Neurotrophins play differential roles in short and long-term recognition memory. Neurobiol Learn Mem. 2013 Sep;104:39-48. doi: 10.1016/j.nlm.2013.04.011. Epub 2013 May 10. PMID: 23669064. 13: Callaghan CK, Kelly ÁM. Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat. Hippocampus. 2012 Nov;22(11):2127-35. doi: 10.1002/hipo.22033. Epub 2012 May 10. PMID: 22573708. 14: Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci. 2011 Jan 5;31(1):15-25. doi: 10.1523/JNEUROSCI.2538-10.2011. PMID: 21209185; PMCID: PMC3078582. 15: Kumar N, Liang Y, Parslow TG, Liang Y. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol. 2011 Mar;85(6):2818-27. doi: 10.1128/JVI.01969-10. Epub 2011 Jan 5. PMID: 21209112; PMCID: PMC3067926. 16: Zhang Z, Oyesanya RA, Campbell DJ, Almenara JA, Dewitt JL, Sirica AE. Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. Hepatology. 2010 Sep;52(3):975-86. doi: 10.1002/hep.23773. PMID: 20607690. 17: Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RP, Maggirwar SB. Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Exp Hematol. 2009 Nov;37(11):1295-309. doi: 10.1016/j.exphem.2009.08.005. Epub 2009 Aug 28. PMID: 19716854; PMCID: PMC2772191. 18: Nilsson E, Dole G, Skinner MK. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition. Reproduction. 2009 Oct;138(4):697-707. doi: 10.1530/REP-09-0179. Epub 2009 Jul 7. PMID: 19584175; PMCID: PMC5728087. 19: Eisinger DA, Ammer H. delta-Opioid receptors stimulate ERK1/2 activity in NG108-15 hybrid cells by integrin-mediated transactivation of TrkA receptors. FEBS Lett. 2008 Oct 15;582(23-24):3325-9. doi: 10.1016/j.febslet.2008.08.021. Epub 2008 Sep 5. PMID: 18775707. 20: Gassei K, Ehmcke J, Schlatt S. Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. Reproduction. 2008 Oct;136(4):459-69. doi: 10.1530/REP-08-0241. Epub 2008 Jul 25. PMID: 18660385.