BML-266 (also known as JFD00244) is a synthetic compound that functions as a selective inhibitor of Sirtuin 2 (SIRT2), a NAD⁺-dependent deacetylase involved in regulating various cellular processes, including gene expression, metabolism, and cell cycle progression. With an IC₅₀ of approximately 56.7 μM, BML-266 has been utilized in research to study its effects on cellular differentiation and proliferation, particularly in cancer cell lines such as the NB4 acute promyelocytic leukemia cells . The compound's structure is characterized by an anthraquinone core substituted with hydroxyphenethylamine groups, contributing to its biological activity
MedKoo Cat#: 562901
Name: BML-266
CAS#: 96969-83-4
Chemical Formula: C30H26N2O4
Exact Mass: 478.1893
Molecular Weight: 478.54
Elemental Analysis: C, 75.30; H, 5.48; N, 5.85; O, 13.37
The following data is based on the product molecular weight 478.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
