10-DEBC free base | CAS#201788-90-1 | Akt phosphorylation inhibitor

MedKoo Cat#: 562826 | Name: 10-DEBC free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

10-DEBC, also known as Akt Inhibitor X and CCG-206734, is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt. Inhibition of Akt phosphorylation by this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.

Chemical Structure

10-DEBC free base

CAS#201788-90-1 (free base)

Theoretical Analysis

MedKoo Cat#: 562826

Name: 10-DEBC free base

CAS#: 201788-90-1 (free base)

Chemical Formula: C20H25ClN2O

Exact Mass: 344.1655

Molecular Weight: 344.88

Elemental Analysis: C, 69.65; H, 7.31; Cl, 10.28; N, 8.12; O, 4.64

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Related CAS #

201788-90-1 (free base) 925681-41-0 (HCl)

Synonym

Akt Inhibitor X; Akt Inhibitor-X; aktX; 10-DEBC hydrochloride; CCG-206734; CCG 206734; CCG206734; NCP;

IUPAC/Chemical Name

4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine

InChi Key

GYBXAGDWMCJZJK-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H25ClN2O/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3

SMILES Code

CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 344.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Varela-M RE, Ochoa R, Muskus CE, Muro A, Mollinedo F. Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis. Parasit Vectors. 2017 Oct 10;10(1):458. doi: 10.1186/s13071-017-2379-y. PubMed PMID: 29017516; PubMed Central PMCID: PMC5633885. 2: Zhang R, Zhu Y, Dong X, Liu B, Zhang N, Wang X, Liu L, Xu C, Huang S, Chen L. Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca(2+) -CaMKII-Dependent Akt/mTOR Pathway. J Cell Physiol. 2017 Aug;232(8):2145-2157. doi: 10.1002/jcp.25703. Epub 2017 Feb 28. PubMed PMID: 27891586. 3: Xu C, Zhang H, Liu C, Zhu Y, Wang X, Gao W, Huang S, Chen L. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget. 2015 Aug 28;6(25):21452-67. PubMed PMID: 26046303; PubMed Central PMCID: PMC4673278. 4: de Oliveira AC, Candelario-Jalil E, Langbein J, Wendeburg L, Bhatia HS, Schlachetzki JC, Biber K, Fiebich BL. Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. J Neuroinflammation. 2012 Jan 3;9:2. doi: 10.1186/1742-2094-9-2. PubMed PMID: 22214188; PubMed Central PMCID: PMC3283507. 5: Lin Y, Sun Z. Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes. J Cell Physiol. 2011 Oct;226(10):2625-32. doi: 10.1002/jcp.22613. PubMed PMID: 21792921; PubMed Central PMCID: PMC3075354. 6: Banquet S, Delannoy E, Agouni A, Dessy C, Lacomme S, Hubert F, Richard V, Muller B, Leblais V. Role of G(i/o)-Src kinase-PI3K/Akt pathway and caveolin-1 in β₂-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery. Cell Signal. 2011 Jul;23(7):1136-43. doi: 10.1016/j.cellsig.2011.02.008. Epub 2011 Mar 6. PubMed PMID: 21385608. 7: Shyu KG, Wang BW, Chen WJ, Kuan P, Hung CR. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Eur J Heart Fail. 2010 Mar;12(3):219-26. doi: 10.1093/eurjhf/hfq011. PubMed PMID: 20156938. 8: Nagahama M, Hagiyama T, Kojima T, Aoyanagi K, Takahashi C, Oda M, Sakaguchi Y, Oguma K, Sakurai J. Binding and internalization of Clostridium botulinum C2 toxin. Infect Immun. 2009 Nov;77(11):5139-48. doi: 10.1128/IAI.00638-09. Epub 2009 Aug 31. PubMed PMID: 19720757; PubMed Central PMCID: PMC2772504. 9: Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlén P, Estrada M. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol. 2009 Aug;202(2):299-307. doi: 10.1677/JOE-09-0044. Epub 2009 May 27. Erratum in: J Endocrinol. 2009 Sep;202(3):485. PubMed PMID: 19474060. 10: Lim CS, Walikonis RS. Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway. Cell Signal. 2008 May;20(5):825-35. doi: 10.1016/j.cellsig.2007.12.013. Epub 2007 Dec 27. PubMed PMID: 18262389; PubMed Central PMCID: PMC2302788.

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